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The CCJ plays a major role in protecting the inferior brainstem (bulb) and spinal cord, therefore also requiring some stability. Children are subjected to multiple constitutive or acquired diseases involving the CCJ: primary bone diseases such as in <jats:italic>FGFR<\/jats:italic>\u2010related craniosynostoses or acquired conditions such as congenital torticollis, cervical spine luxation, and neurological disorders. To design efficient treatment plans, it is crucial to understand the relationship between abnormalities of the craniofacial region and abnormalities of the CCJ. This can be approached by the study of control and abnormal growth patterns. Here we report a model of normal skull base growth by compiling a collection of geometric models in control children. Focused analyses highlighted specific developmental patterns for each CCJ bone, emphasizing rapid growth during infancy, followed by varying rates of growth and maturation during childhood and adolescence until reaching stability by 18\u2009years of age. The focus was on the closure patterns of synchondroses and sutures in the occipital bone, revealing distinct closure trajectories for the anterior intra\u2010occipital synchondroses and the occipitomastoid suture. The findings, although based on a limited dataset, showcased specific age\u2010related changes in width and closure percentages, providing valuable insights into growth dynamics within the first 2\u2009years of life. Integration analyses revealed intricate relationships between skull and neck structures, emphasizing coordinated growth at different stages. Specific bone covariation patterns, as found between the first and second cervical vertebrae (C1 and C2), indicated synchronized morphological changes. Our results provide initial data for designing inclusive CCJ geometric models to predict normal and abnormal growth dynamics.<\/jats:p>","DOI":"10.1111\/joa.14067","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T06:30:28Z","timestamp":1716532228000},"page":"842-863","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Geometric growth of the normal human craniocervical junction from 0 to 18\u2009years old"],"prefix":"10.1111","volume":"245","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5354-7626","authenticated-orcid":false,"given":"Juliette","family":"Raoul\u2010Duval","sequence":"first","affiliation":[{"name":"Craniofacial Growth and Form H\u00f4pital Necker \u2013 Enfants Malades, Assistance Publique \u2013 H\u00f4pitaux de Paris  Paris 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