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Trying to overcome the \u201ccorrespondence problem,\u201d we applied a landmark\u2010free method (the generalized procrustes surface analysis (GPSA)) for investigating the shape variation of cortical surface in a group of 40 healthy volunteers (i.e., the practice group) subjected to daily motor training known as Quadrato motor training (QMT). QMT is a sensorimotor walking meditation that aims at balancing body, cognition, and emotion. More specifically, QMT requires coordination and attention and consists of moving in one of three possible directions on corners of a 50\u2009\u00d7\u200950\u2009cm<jats:sup>2<\/jats:sup>. Brain magnetic resonance images (MRIs) of practice group (acquired at baseline, as well as after 6 and 12\u2009weeks of QMT), were 3D reconstructed and here compared with brain MRIs of six more volunteers never practicing the QMT (na\u00efve group). Cortical regions mostly affected by morphological variations were visualized on a 3D average color\u2010scaled brain surface indicating from higher (red) to lower (blue) levels of variation. Cortical regions interested in most of the shape variations were as follows: (1) the supplementary motor cortex; (2) the inferior frontal gyrus (<jats:italic>pars opercolaris<\/jats:italic>) and the anterior insula; (3) the visual cortex; (4) the inferior parietal lobule (supramarginal gyrus and angular gyrus). Our results show that surface morphometric analysis (i.e., GPSA) can be applied to assess brain neuroplasticity processes, such as those stimulated by QMT.<\/jats:p>","DOI":"10.1111\/joa.14104","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T09:05:37Z","timestamp":1719392737000},"page":"757-769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Assessing brain neuroplasticity: Surface morphometric analysis of cortical changes induced by Quadrato motor training"],"prefix":"10.1111","volume":"246","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9577-8875","authenticated-orcid":false,"given":"F.","family":"Spani","sequence":"first","affiliation":[{"name":"Department of Science and Technology for Sustainable Development and One Health Universit\u00e0 Campus Bio\u2010Medico di Roma  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Carducci","sequence":"additional","affiliation":[{"name":"Neuroimaging Laboratory, Department of Physiology and Pharmacology Sapienza University of Rome (IT)  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Piervincenzi","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences Sapienza University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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