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We aimed to investigate the effects of transauricular vagal nerve stimulation (tVNS) on inflammation in rats with IBD induced by trinitrobenzene sulfonic acid (TNBS). A total of 36 adult female Sprague\u2013Dawley rats were given TNBS, or vehicle, and tVNS, or sham, every other day for 30\u2009min for 10\u2009days. Postmortem macroscopic and microscopic colon morphology were evaluated by histological staining. Additionally, IL\u20101\u03b2, IL\u20106, IL\u201010, and TNF\u2010\u03b1 cytokine levels in the colon and the brain were evaluated by immunohistochemistry and western blotting analysis. TNBS induced epithelial damage, inflammation, ulceration, and thickened mucosal layer in the colonic tissues. Administration of tVNS significantly ameliorated the severity of TNBS\u2010induced tissue damage and inflammatory response. TNBS also alters pro\u2010inflammatory and anti\u2010inflammatory balance in the brain tissue. TVNS application significantly suppressed the protein levels of pro\u2010inflammatory cytokines, namely IL\u20101\u03b2, IL\u20106, and TNF\u2010 \u03b1 while augmenting the level of anti\u2010inflammatory cytokine IL\u201010 in the colonic and the brain tissue. We have shown that TNBS\u2010mediated colonic inflammation and tissue damage are associated with neuroinflammatory responses in the brain tissue. Also demonstrated for the first time that neuroinflammatory response in the gut\u2010brain axis is suppressed by tVNS in the IBD model. Non\u2010invasive tVNS stands out as a new potential treatment option for types of IBD.<\/jats:p>","DOI":"10.1111\/joa.14178","type":"journal-article","created":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T04:25:46Z","timestamp":1734755146000},"page":"602-615","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Transauricular vagal nerve stimulation suppresses inflammatory responses in the gut and brain in an inflammatory bowel disease model"],"prefix":"10.1111","volume":"246","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1239-1144","authenticated-orcid":false,"given":"Kerem","family":"Atalar","sequence":"first","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine Neuroscience and Neurotechnology Center of Excellence (N\u00d6ROM) and Neuropsychiatry Center, Gazi University  Ankara 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