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Current clinical decisions with regards to surgical planning and\/or radiological intervention are guided by geometric features, such as aortic diameter, since clinical imaging lacks tissue microstructural information. The aim of this proof\u2010of\u2010concept work is to investigate a non\u2010invasive imaging method, diffusion tensor imaging (DTI), in ex\u00a0vivo aortic tissue to gain insights into the microstructure. This study examines healthy, aneurysm and a type B chronic dissection aortae, via DTI. DTI\u2010derived metrics, such as the fractional anisotropy, mean diffusivity, helical angle and tractography, were examined in each morphology. The results from this work highlighted distinct differences in fractional anisotropy (healthy, 0.24\u2009\u00b1\u20090.008; aneurysmal, 0.19\u2009\u00b1\u20090.002; dissected, 0.13\u2009\u00b1\u20090.006) and a larger variation in the helical angle in the dissected aorta compared to healthy (39.28\u2009\u00b1\u200911.93\u00b0 vs. 26.12\u2009\u00b1\u20094.60\u00b0, respectively). These differences were validated by histological characterisation. This study demonstrates the sensitivity of DTI to pathological changes in aortic tissue, highlighting the potential of this methodology to provide improved clinical insight.<\/jats:p>","DOI":"10.1111\/joa.14223","type":"journal-article","created":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T18:25:06Z","timestamp":1737915906000},"page":"745-756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A preliminary ex\u00a0vivo diffusion tensor imaging study of distinct aortic morphologies"],"prefix":"10.1111","volume":"246","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4359-9012","authenticated-orcid":false,"given":"B.","family":"Tornifoglio","sequence":"first","affiliation":[{"name":"Trinity Centre for Biomedical Engineering Trinity Biomedical Sciences Institute, Trinity College Dublin  Dublin Ireland"},{"name":"Discipline of Mechanical, Manufacturing, and Biomedical Engineering School of Engineering, Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6949-8239","authenticated-orcid":false,"given":"S. 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