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It is larger in humans than in other primates, and it is affected by atrophy and hypometabolism in the early stages of Alzheimer's disease (AD). In this study, we compare its general morphology in normal aging subjects and AD patients, considering its geometry through shape analysis, and the atrophy at its boundary by quantifying the intersulcal spacing. Results suggest that the AD sample displays a reduction of the inferior regions of the precuneus, namely those that fade into the posterior cingulate and retrosplenial cortex. During aging, sulcal spacing is pronounced at the superior and posterior regions, although in the AD sample the latter change is more marked. However, these differences are associated with a remarkable individual variation and a consistent overlap between group ranges. This study stresses further the differences between the dorsal and ventral regions of the precuneus. Beyond functional factors, the dorsal areas represent a region of scarce spatial constraints, whereas the ventral regions are embedded in a complex topological environment. This structural difference must be considered when investigating cortical morphology in both normal and pathological conditions.<\/jats:p>","DOI":"10.1111\/joa.70027","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T08:59:57Z","timestamp":1756457997000},"page":"62-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Morphological variations and cortical atrophy of the precuneus in normal aging and Alzheimer's disease"],"prefix":"10.1111","volume":"248","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6686-4616","authenticated-orcid":false,"given":"Emiliano","family":"Bruner","sequence":"first","affiliation":[{"name":"Museo Nacional de Ciencias Naturales, CSIC  Madrid Spain"},{"name":"Reina Sofia Foundation Alzheimer Center, CIEN Foundation, ISCIII  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9006-4125","authenticated-orcid":false,"given":"Rafael","family":"Gallareto\u2010Sande","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaci\u00f3n Sobre la Evoluci\u00f3n Humana  Burgos Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"L\u00f3pez\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Reina Sofia Foundation Alzheimer Center, CIEN Foundation, ISCIII  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Zhang","sequence":"additional","affiliation":[{"name":"Reina Sofia Foundation Alzheimer Center, CIEN Foundation, ISCIII  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"S\u00e1nchez Mart\u00edn","sequence":"additional","affiliation":[{"name":"Reina Sofia Foundation Alzheimer Center, CIEN Foundation, ISCIII  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel J.","family":"Grothe","sequence":"additional","affiliation":[{"name":"Reina Sofia Foundation Alzheimer Center, CIEN Foundation, ISCIII  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascual","family":"S\u00e1nchez\u2010Juan","sequence":"additional","affiliation":[{"name":"Reina Sofia Foundation Alzheimer Center, CIEN Foundation, ISCIII  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1818512116"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.24941"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-99193-3.00006-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12355"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010122299"},{"key":"e_1_2_9_7_1","first-page":"181","volume-title":"The evolutionary roots of human brain diseases","author":"Bruner E.","year":"2024"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.20714"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2017.02.003"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429\u2010020\u201002152\u20100"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12155"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2017.10.022"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2014.01385"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1214083"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23429"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad181"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1814117115"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429\u2010010\u20100283\u20108"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429\u2010013\u20100546\u20102"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2059\u201023.2024"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giae049"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23018"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.4404\/hystrix\u201024.1\u20106292"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060159"},{"key":"e_1_2_9_27_1","unstructured":"Hammer O. 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