{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T04:03:58Z","timestamp":1780113838990,"version":"3.54.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Rheumatoid arthritis (RA) is an autoimmune disease that primarily affects hyaline cartilage, except in the case of the temporomandibular joint (TMJ), which is covered by fibrocartilage. This study compared the progression of RA in these two types of cartilage by examining the TMJ and knee joints of rats in both the acute and chronic phases of the disease. Forty\u2010eight male Wistar rats were divided into groups: Control (animals without RA in the TMJ or knee), RA\u201024h, and RA\u20107d (animals with RA in the TMJ or knee, euthanized 24\u2009h or 7\u2009days after the last intra\u2010articular injection, respectively). The rats were sensitized with subcutaneous injections containing complete\/incomplete Freund's adjuvant and methylated bovine serum albumin (mBSA), followed by three intra\u2010articular mBSA injections (one per week) into either the TMJ or knee. Euthanasia was performed 24\u2009h (acute phase) or 7\u2009days (chronic phase) after the third injection. The following parameters were assessed: nociceptive thresholds, cellular influx in synovial fluid, histopathology, immunohistochemistry for metalloproteinase\u20109 (MMP\u20109), and birefringence of collagen fibers in articular cartilage. A significant reduction in the nociceptive threshold was observed in arthritic animals in both joints compared to the control groups. Additionally, a significant increase in cellular influx in the synovial membrane was noted in both joints after the third mBSA injection, as well as in the knee after 7\u2009days. Histopathological analysis revealed reduced metachromasia, increased MMP\u20109 immunoexpression, and higher levels of type III collagen in the articular cartilage compared to the respective controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The nociceptive response was similar in both joints during the acute and chronic phases of RA. However, evidence of articular repair was observed in the TMJ, accompanied by a sustained reduction in the nociceptive threshold, suggesting central sensitization without ongoing peripheral damage.\n                  <\/jats:p>","DOI":"10.1111\/joa.70080","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T06:55:16Z","timestamp":1765176916000},"page":"114-126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is the temporomandibular joint affected by rheumatoid arthritis? A comparative investigation with knee arthritis in an experimental rat model"],"prefix":"10.1111","volume":"249","author":[{"given":"Ana Carolina de Figueiredo","family":"Costa","sequence":"first","affiliation":[{"name":"Postgraduate Program in Dentistry, Faculty of Pharmacy, Dentistry and Nursing Federal University of Cear\u00e1  Fortaleza CE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luane Macedo","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Morphofunctional Sciences, Faculty of Medicine Federal University of Cear\u00e1  Fortaleza CE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7240-3314","authenticated-orcid":false,"given":"Delane Viana","family":"Gondim","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry, Faculty of Pharmacy, Dentistry and Nursing Federal University of Cear\u00e1  Fortaleza CE Brazil"},{"name":"Postgraduate Program in Morphofunctional Sciences, Faculty of Medicine Federal University of Cear\u00e1  Fortaleza CE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-020-04731-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37686"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2021.07.003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-019-0072-z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2019.1559050"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173636"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2021.07.002"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_307_20"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2018.11.072"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102735"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-019-01274-4"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2022.101649"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2022.116523"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008207.2021.1873962"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.01.138"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41752"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10690"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/08869634.2020.1826174"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-020-01313-x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2017.11.002"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24130"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020905"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-021-00993-0"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/jdb4030025"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15031003"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.5114\/ceji.2017.72807"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2012.02727.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani10061047"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2018.07.003"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16514"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040880"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.04.035"},{"issue":"1","key":"e_1_2_9_34_1","article-title":"Prevalence and severity of temporomandibular disorders in rheumatoid arthritis patients","volume":"14","author":"Mustafa M.A.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00056-021-00309-y"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.07.002"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10112857"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072358"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573397114666180806142814"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.102400"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(98)90871-0"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.123919"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.15557\/JoU.2013.0019"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.612104"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400206"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/1744806917724559"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2013.08.022"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202249962"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6245798"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-018-0473-5"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-018-0254-4"}],"container-title":["Journal of Anatomy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joa.70080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/joa.70080","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joa.70080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T03:26:02Z","timestamp":1780111562000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joa.70080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,7]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/joa.70080"],"URL":"https:\/\/doi.org\/10.1111\/joa.70080","archive":["Portico"],"relation":{},"ISSN":["0021-8782","1469-7580"],"issn-type":[{"value":"0021-8782","type":"print"},{"value":"1469-7580","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,7]]},"assertion":[{"value":"2025-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}