{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:54:46Z","timestamp":1782975286586,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD109232"],"award-info":[{"award-number":["R01HD109232"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK123641"],"award-info":[{"award-number":["R01DK123641"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cilia are finger\u2010like organelles protruding from the cell membrane, and dysfunction of cilia can cause human diseases called ciliopathies with a range of phenotypes. Some ciliopathies include pituitary phenotypes, and previous studies have shown a role for non\u2010motile primary cilia in pituitary organogenesis. In this study, we generated a pituitary gland\u2010conditional knockout of the ciliary basal body protein CEP164 to investigate the role of primary cilia in pituitary development and postnatal function. Our mouse model shows a loss of pituitary primary cilia between e14.5 and e18.5, although pituitary organogenesis and morphology appear normal in late embryos and postpubertal mice of both sexes. No physiological defects were noted in postpubertal mice, although there were minor changes in the expression of\n                    <jats:italic>Sox2<\/jats:italic>\n                    and\n                    <jats:italic>Prl<\/jats:italic>\n                    transcripts. We conclude that primary cilia are dispensable in late pituitary organogenesis, therefore suggesting the role of primary cilia occurs during early pituitary development. Further studies may investigate whether cilia are required for specific responses to physiological or pathological conditions where endocrine needs are altered.\n                  <\/jats:p>","DOI":"10.1111\/joa.70204","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:22:16Z","timestamp":1782969736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Loss of primary cilia in late pituitary organogenesis does not cause endocrine dysfunction"],"prefix":"10.1111","author":[{"given":"Kevin","family":"Byun","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics Stony Brook University  Stony Brook New York USA"},{"name":"Molecular and Cellular Pharmacology Graduate Program Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Qian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken\u2010Ichi","family":"Takemaru","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0912-9594","authenticated-orcid":false,"given":"Leonard Y. M.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2018-229016","article-title":"Joubert syndrome with multiple pituitary hormone deficiency","volume":"12","author":"Akcan N.","year":"2019","journal-title":"BMJ Case Reports"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000513829","article-title":"Identification of the TTC26 splice variant in a novel complex ciliopathy syndrome with biliary, renal, neurological, and skeletal manifestations","volume":"12","author":"Alfadhel M.","year":"2021","journal-title":"Molecular 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