{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:15:56Z","timestamp":1789539356193,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T00:00:00Z","timestamp":1353628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>P<\/jats:styled-content>ropionibacterium acnes<\/jats:italic> is a major contributing factor to the inflammatory component of acne. The interaction of P<\/jats:styled-content>.\u00a0acnes<\/jats:italic> with keratinocytes leads to an innate immune response via activation of toll\u2010like receptors (TLR<\/jats:styled-content>2, TLR<\/jats:styled-content>4) resulting in the production and secretion of pro\u2010inflammatory mediators. SIG<\/jats:styled-content>1273, an isoprenylcysteine small molecule modulates inflammatory signaling pathways and kills P<\/jats:styled-content>.\u00a0acnes<\/jats:italic>. SIG<\/jats:styled-content>1273 represents a novel cosmetic functional ingredient that provides relief from blemishes in acne prone skin.<\/jats:p><\/jats:sec>Objective<\/jats:title>To assess the keratinocyte response and microbial growth of SIG<\/jats:styled-content>1273 in vitro<\/jats:italic> and evaluate the tolerability of SIG<\/jats:styled-content>1273 gel applied topically in acne prone subjects.<\/jats:p><\/jats:sec>Methods<\/jats:title>For in vitro<\/jats:italic> studies, human keratinocytes were exposed in culture to live P<\/jats:styled-content>.\u00a0acnes<\/jats:italic> and peptidoglycan (PGN<\/jats:styled-content>) to induce IL<\/jats:styled-content>\u20108 production. P<\/jats:styled-content>.\u00a0acnes<\/jats:italic> were cultured to determine minimal inhibitory concentration and minimal bactericidal concentration values. A total of 30 subjects were randomized in a double\u2010blind controlled trial receiving 3% SIG<\/jats:styled-content>1273 gel or vehicle for 6\u00a0weeks. Evaluation included inflammatory lesions, noninflammatory lesions, microcomedones, S<\/jats:styled-content>ebutape scores, and P<\/jats:styled-content>.\u00a0acnes<\/jats:italic> counts.<\/jats:p><\/jats:sec>Results<\/jats:title>In vitro<\/jats:italic> studies demonstrate SIG<\/jats:styled-content>1273 inhibits P<\/jats:styled-content>.\u00a0acnes<\/jats:italic>\u2010induced IL<\/jats:styled-content>\u20108 production and inhibits P<\/jats:styled-content>.\u00a0acnes<\/jats:italic> growth. SIG<\/jats:styled-content>1273 gel was well tolerated with no signs of stinging, redness, or itching. Furthermore, improvement in some aspects of acne was observed in subjects applying SIG<\/jats:styled-content>1273 gel, including inflammatory lesions, microcomedone counts and S<\/jats:styled-content>ebutape scores. Facial scrubs taken to measure P<\/jats:styled-content>.\u00a0acnes<\/jats:italic> colony\u2010forming units showed those applying SIG<\/jats:styled-content>1273 gel had ~1.0 L<\/jats:styled-content>og 10 colony reduction over the length of the study, a statistically significantly improvement when compared with vehicle. No significant effects above vehicle were observed for noninflammatory lesions.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>SIG<\/jats:styled-content>1273 represents a novel cosmetic functional ingredient that provides a safe dual modulating benefit to individuals with acne prone skin by reducing P<\/jats:styled-content>.\u00a0acnes<\/jats:italic> counts and reducing inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12002","type":"journal-article","created":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T10:42:27Z","timestamp":1353667347000},"page":"272-278","source":"Crossref","is-referenced-by-count":15,"title":["SIG<\/scp>1273: a new cosmetic functional ingredient to reduce blemishes and P<\/scp>ropionibacterium acnes<\/i> in acne prone skin"],"prefix":"10.1111","volume":"11","author":[{"given":"Jos\u00e9 R","family":"Fernand\u00e9z","sequence":"first","affiliation":[{"name":"Signum Dermalogix Monmouth Junction New Jersey USA"},{"name":"Signum Biosciences Monmouth Junction New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Rouzard","sequence":"additional","affiliation":[{"name":"Signum Dermalogix Monmouth Junction New Jersey USA"},{"name":"Signum Biosciences Monmouth Junction New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Voronkov","sequence":"additional","affiliation":[{"name":"Signum Dermalogix Monmouth Junction New Jersey USA"},{"name":"Signum Biosciences Monmouth Junction New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyan","family":"Feng","sequence":"additional","affiliation":[{"name":"Signum Dermalogix Monmouth Junction New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffry B","family":"Stock","sequence":"additional","affiliation":[{"name":"Signum Biosciences Monmouth Junction New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell","family":"Stock","sequence":"additional","affiliation":[{"name":"Signum Dermalogix Monmouth Junction New Jersey USA"},{"name":"Signum Biosciences Monmouth Junction New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel S","family":"Gordon","sequence":"additional","affiliation":[{"name":"Signum Dermalogix Monmouth Junction New Jersey USA"},{"name":"Signum Biosciences Monmouth Junction New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Braham","family":"Shroot","sequence":"additional","affiliation":[{"name":"Signum Dermalogix Monmouth Junction New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S","family":"Christensen","sequence":"additional","affiliation":[{"name":"Springhouse Skin Research Merion Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Signum Dermalogix Monmouth Junction New Jersey USA"},{"name":"Signum Biosciences Monmouth Junction New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1988.tb01775.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.03.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2038"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087011"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.3.1535"},{"key":"e_1_2_7_7_1","first-page":"1308","article-title":"CBT\u2010SL5, a bacteriocin from Enterococcus faecalis, suppresses the expression of interleukin\u20108 induced by Propionibacterium acnes in cultured human keratinocytes","volume":"18","author":"Lee YJ","year":"2008","journal-title":"J Microbiol Biotechnol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06933.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2006.04.001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/41131"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a133918"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1612"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)54669-X"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.3.868"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8438158"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701061"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.334"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.93"},{"key":"e_1_2_7_19_1","first-page":"492","article-title":"Zinc salts inhibit in vitro Toll\u2010like receptor 2 surface expression by keratinocytes","volume":"17","author":"Jarrousse V","year":"2007","journal-title":"Eur J Dermatol"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.12.5.672-675.1980"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200102040-00007"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(02)80023-6"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12002","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T11:04:54Z","timestamp":1697367894000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,23]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/jocd.12002"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12002","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,23]]}}}