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One potent antioxidant of particular note, vitamin <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>, has been extensively utilized because it possesses a variety of other cutaneous benefits including photoprotection from <jats:styled-content style=\"fixed-case\">UV A &amp; B<\/jats:styled-content>, neocollagenesis, inhibition of melanogenesis and improvement of a variety of inflammatory skin disorders. However, the instability of this water\u2010soluble vitamin, together with difficulties associated with its topical delivery, has presented issues for the formulation chemist. This article reviews the scientific data and clinical studies that underpin the stability, percutaneous absorption, and cutaneous effects of vitamin <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> together with its commonly utilized, commercially available derivatives.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12006","type":"journal-article","created":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T10:42:27Z","timestamp":1353667347000},"page":"310-317","source":"Crossref","is-referenced-by-count":131,"title":["Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivatives"],"prefix":"10.1111","volume":"11","author":[{"given":"Nicholas P J","family":"Stamford","sequence":"first","affiliation":[{"name":"Ultraceuticals Pty Ltd Gladesville NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(95)00158-C"},{"key":"e_1_2_8_3_1","first-page":"115","article-title":"A new stabilized ascorbic acid solution: percutaneous absorption and effect on realtive collagen synthesis","volume":"1","author":"Kaplan MD","year":"1989","journal-title":"J Cut Aging Cos Derm"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb00122.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.46.174"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000081115"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2001.00264.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2005.31725"},{"key":"e_1_2_8_9_1","first-page":"96","volume-title":"Handbook of Antioxidants","author":"Buettner GR","year":"1996"},{"key":"e_1_2_8_10_1","first-page":"473","article-title":"A stabilised ascorbic acid solution","volume":"24","author":"Tsao CS","year":"1996","journal-title":"Med Sci Res"},{"key":"e_1_2_8_11_1","first-page":"1237","article-title":"Photostability of ascorbic acid in aqueous and organic solvents","volume":"3","author":"Ahmad I","year":"2010","journal-title":"J Pharm Res"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000078824"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(99)00228-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(96)01904-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-011-9659-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.5012\/bkcs.2003.24.4.499"},{"key":"e_1_2_8_17_1","first-page":"1","article-title":"The stabilization of L\u2010ascorbic acid in aqueous solution and water\u2010in\u2010oil\u2010in\u2010water double emulsion by controlling pH and electrolyte concentration","volume":"55","author":"Lee JS","year":"2004","journal-title":"J Cosmet Sci"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-8453.86296"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1996.tb02447.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2008.00288.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12537.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0909-752X.2006.00186.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-010-0863-0"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(01)00715-3"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2008.00473.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.38.3020"},{"key":"e_1_2_8_27_1","volume-title":"BV\u2010OSC (tetrahexyldecyl ascorbate); a stable, oil\u2010soluble form of vitamin C. 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