{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:58:28Z","timestamp":1780462708733,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T00:00:00Z","timestamp":1353628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris is one of the most common dermatological diseases, and its pathogenesis is multifactorial. Although there are some reports about role of oxidative stress biomarkers in blood, serum, plasma in the pathogenesis of acne, there has been no report about oxidative stress biomarkers in scraping samples. For this reason, the aim of our study is to determine the role of oxidative stress biomarkers and adenosine deaminase (<jats:styled-content style=\"fixed-case\">ADA<\/jats:styled-content>) in scraping samples of acne lesion and to determine a possible link with the clinical severity. Fifty patients with different severity of acne vulgaris and forty healthy controls were enrolled. In both groups, <jats:styled-content style=\"fixed-case\">ADA<\/jats:styled-content> and oxidative stress biomarkers such as the levels of malondialdehyde (<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>), and reduced glutathione (<jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content>), the activities of superoxide dismutase (<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>) and catalase (<jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content>) in scraping samples were measured spectrophotometrically. The levels of <jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CAT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> GSH<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> MDA<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">ADA<\/jats:styled-content> of patients with acne were higher than the control patients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). <jats:styled-content style=\"fixed-case\">ADA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content> levels in patients with severe acne were significantly higher about two\u2010 to four\u2010fold compared with other acne groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). However, <jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SOD<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content> levels were lower in patients with severe acne vulgaris than the others (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Increased antioxidant enzyme levels of scraping samples in patients might be a local response of the organism to increased oxidative stress. Also, we believe that oxidative stress increases in parallel with the disease severity, hence antioxidant therapy may be beneficial if given in addition to the routine treatment of severe acne.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12011","type":"journal-article","created":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T10:42:27Z","timestamp":1353667347000},"page":"323-328","source":"Crossref","is-referenced-by-count":15,"title":["The activity of adenosine deaminase and oxidative stress biomarkers in scraping samples of acne lesions"],"prefix":"10.1111","volume":"11","author":[{"given":"Ozturk","family":"Perihan","sequence":"first","affiliation":[{"name":"Department of Dermatology Medicine Faculty Sutcuimam University Kahramanmaras Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurutas B","family":"Ergul","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Medicine Faculty Sutcuimam University Kahramanmaras Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dokur","family":"Neslihan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medicine Faculty Sutcuimam University Kahramanmaras Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atalay","family":"Filiz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Medicine Faculty Sutcuimam University Kahramanmaras Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2007.01.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03505.x"},{"key":"e_1_2_9_4_1","first-page":"39","article-title":"Superoxide dismutase and myeloperoxidase activities in polymorphonuclear leukocytes in acne vulgaris","volume":"14","author":"Kurutas EB","year":"2005","journal-title":"Acta Dermatovenereol Alp Panonica Adriat"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2005.03.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/MI.2005.380"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00751.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365548.1981.11690366"},{"key":"e_1_2_9_9_1","first-page":"274","article-title":"Serum adenosine deaminase levels in patients with psoriasis: a prospective case\u2010control study","volume":"10","author":"Bukulmez G","year":"2000","journal-title":"Eur J Dermatol"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00099.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_9_12_1","volume-title":"Red Cell Metabolism. 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