{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:48:24Z","timestamp":1782272904137,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Union Swiss"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cumulative lifetime sun exposure is accepted as having a very important role to play in the expression of the signs of photoaging, which is then superimposed on the intrinsic processes involved in the chronological aging of skin. Many groups have evaluated the effects of emulsion\u2010based products, mostly although not exclusively, on the face using a variety of actives including retinoids and antioxidants. Nevertheless, the effect of a topical anhydrous product on photodamaged skin has not been reported in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The objective of this study was to clinically evaluate the effect of a vitamin <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> palmitate and antioxidant\u2010containing oil\u2010based moisturizer on facial, neck, decolletage, arms, and lower leg body sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a randomized, controlled and efficacy grader\u2010blinded clinical study conducted over 12 weeks, while at the same time recording the changes in skin condition for a no\u2010treatment group over the same time period, live clinical expert grading of all body sites and also grading of photographs for the face and neck assessed changes in the signs of photodamage was performed for the treatment and no\u2010treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the no\u2010treatment group, and to baseline, the oil improved fine lines, coarse wrinkles, mottled pigmentation, uneven skin tone, roughness, firmness, and clarity of the skin on the face and neck and was also shown to improve crepey skin texture, dryness, scaling and roughness on the decolletage, arms and lower legs at the primary end point at 12\u00a0weeks (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Moreover, improvements in a variety of parameters were observed as quickly as 2\u00a0weeks. In general, the degree of improvement was greatest in the order legs\u00a0&gt;\u00a0arms\u00a0&gt;\u00a0decolletage\u00a0&gt;\u00a0face\u00a0&gt;\u00a0neck.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Collectively, these results show the cumulative improvements in the signs of photoaging compared to a no\u2010treatment control group for the oil\u2010based antiaging moisturizer for the first time. The differences in the efficacy of the vitamin A palmiate and antioxidant oil\u2010based moisturizer on different body sites probably reflect the differences in likely photodamage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12023","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T09:45:33Z","timestamp":1361871933000},"page":"25-35","source":"Crossref","is-referenced-by-count":15,"title":["The effect of a vitamin A palmitate and antioxidant\u2010containing oil\u2010based moisturizer on photodamaged skin of several body sites"],"prefix":"10.1111","volume":"12","author":[{"given":"Anthony V","family":"Rawlings","sequence":"first","affiliation":[{"name":"AVR Consulting Ltd Northwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J","family":"Stephens","sequence":"additional","affiliation":[{"name":"Thomas J. Stephens &amp; Associates Inc Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H","family":"Herndon","sequence":"additional","affiliation":[{"name":"Presbyterian Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monae","family":"Miller","sequence":"additional","affiliation":[{"name":"Thomas J. Stephens &amp; Associates Inc Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Thomas J. 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