{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T17:10:16Z","timestamp":1784567416683,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperpigmentation and solar damage remains a difficult problem to treat with topical agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate a novel skin\u2010lightening complex (<jats:styled-content style=\"fixed-case\">SLC<\/jats:styled-content>) comprising four actives targeting melanin formation at multiple levels, namely disodium glycerophosphate, <jats:sc>l<\/jats:sc>\u2010leucine, phenylethyl resorcinol, and undecylenoyl phenylalanine, in an oil\u2010in\u2010water emulsion cream.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients \u2044Methods<\/jats:title><jats:p>Skin\u2010lightening complex was evaluated in 80 female subjects of skin types I\u2013III with at least moderate mottled hyperpigmentation. After a wash\u2010out period of 1\u00a0month with a sunscreen, the subjects added a cream containing the <jats:styled-content style=\"fixed-case\">SLC<\/jats:styled-content> for 12\u00a0weeks twice daily to entire face and continued the sunscreen use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Whereas there was no significant change during the wash\u2010out period, the primary endpoint mottled hyperpigmentation decreased by 32% after the 12\u2010week treatment period with the <jats:styled-content style=\"fixed-case\">SLC<\/jats:styled-content> cream. Secondary endpoints such as severity and number of lentigines, skin tone, and skin brightness also improved. In all, 57% of the subjects showed at least a moderate response, 17% did not improve, and 3% got worse after the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The SLC cream was well tolerated, in particular when comparing with exfoliating or peeling agent containing skin\u2010lightening products. When used with a daily sunscreen, this study confirms that the <jats:styled-content style=\"fixed-case\">SLC<\/jats:styled-content> represents an alternative to hydroquinone, retinoids, and many other skin\u2010lightening actives.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12025","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T09:45:33Z","timestamp":1361871933000},"page":"12-17","source":"Crossref","is-referenced-by-count":19,"title":["Efficacy of hydroquinone\u2010free skin\u2010lightening cream for photoaging"],"prefix":"10.1111","volume":"12","author":[{"given":"Frank","family":"Dreher","sequence":"first","affiliation":[{"name":"Neocutis, Inc. San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe D.","family":"Draelos","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine Department of Dermatology Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Gold","sequence":"additional","affiliation":[{"name":"Gold Skin Care Center Nashville TN USA"},{"name":"Tennessee Clinical Research Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchel P.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Goldman Butterwick Fitzpatrick Groff &amp; Fabi Cosmetic Laser Dermatology San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina G.","family":"Fabi","sequence":"additional","affiliation":[{"name":"Goldman Butterwick Fitzpatrick Groff &amp; Fabi Cosmetic Laser Dermatology San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary L.","family":"Puissegur Lupo","sequence":"additional","affiliation":[{"name":"Lupo Center for Aesthetic &amp; General Dermatology New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2800721"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.8.4002"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1241"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2006.00425.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2007.00397.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2004.09.014"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00334.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.02.020"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/ciia.2006.1.4.327"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2007.00144.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2011.00573.x"},{"key":"e_1_2_5_13_1","first-page":"12","article-title":"Comparison of a skin lightening cream targeting melanogenesis on multiple levels to triple combination cream for melasma","author":"Monheit GD","year":"2013","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2000.009003165.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.06.021"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.30.677"},{"key":"e_1_2_5_17_1","first-page":"2","article-title":"4\u2010(1\u2010Phenylethyl)1,3\u2010benzenediol: a new, highly efficient lightening agent","volume":"9","author":"Vielhaber G","year":"2006","journal-title":"IFSCC Magazine"},{"key":"e_1_2_5_18_1","unstructured":"StoltzC GarciaC.Use of a compound inactivating the kinase A protein in a composition containing a cosmetically acceptable medium in order to lighten the skin. 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