{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:45:45Z","timestamp":1783637145063,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T00:00:00Z","timestamp":1370217600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The efficacy of topical retinoids is well known according to several clinical studies conducted predominantly among <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>aucasian patients. This study aimed to evaluate the efficacy and safety profile of adapalene and tretinoin among <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>exican patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare adapalene 0.1 and 0.3% and tretinoin 0.05% in <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>exican subjects with acne vulgaris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 171 patients in this single\u2010center, randomized, double\u2010blinded, placebo\u2010controlled clinical trial. The patients applied on the face either adapalene 0.1%, adapalene 0.3%, tretinoin 0.05%, or placebo for 90\u00a0days and were evaluated for the reduction in total lesion counts and for the level of irritation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tretinoin 0.05% and adapalene 0.3% were more effective than adapalene 0.1% and placebo in the reduction of both inflammatory and noninflammatory lesions. Most of adverse events to adapalene and many on tretinoin group were related to skin irritation, dry skin, scaling, pruritus, burning, and postinflammatory hyperpigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adapalene 0.3% and tretinoin 0.05% are comparable in efficacy, and adapalene 0.1% offers a better safety profile in <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>exican patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12031","type":"journal-article","created":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T09:53:40Z","timestamp":1370253220000},"page":"103-107","source":"Crossref","is-referenced-by-count":23,"title":["Efficacy and safety of adapalene gel 0.1% and 0.3% and tretinoin gel 0.05% for acne vulgaris: results of a single\u2010center, randomized, double\u2010blinded, placebo\u2010controlled clinical trial on <scp>M<\/scp>exican patients (skin type <scp>III<\/scp>\u2013<scp>IV<\/scp>)"],"prefix":"10.1111","volume":"12","author":[{"given":"Andr\u00e9s","family":"Tirado\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital General de M\u00e9xico M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yareni Salas","family":"Esp\u00edndola","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General de M\u00e9xico M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Mar\u00eda","family":"Ponce\u2010Olivera","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General de M\u00e9xico M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandro","family":"Bonifaz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General de M\u00e9xico M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328282"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2011.05.2294"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2008.06741_suppx.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1999.tb06229.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120791"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1396-0296.2004.04019.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630902763164"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/0128071-200809060-00003"},{"key":"e_1_2_5_10_1","first-page":"41","article-title":"Management strategies for acne vulgaris","volume":"4","author":"Whitney KM","year":"2011","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.10.879"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70054-9"},{"key":"e_1_2_5_13_1","first-page":"350","article-title":"Randomised, controlled trial of the efficacy and safety of adapalene gel 0.1% and tretinoin cream 0.05% in patients with acne vulgaris","volume":"12","author":"Cunliffe WJ","year":"2002","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00254.x"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12031","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12031","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T07:38:29Z","timestamp":1697355509000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/jocd.12031"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12031","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}