{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T02:38:38Z","timestamp":1789353518919,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Different laser systems are reported to be effective in treatment of telangiectasia and erythema, but comparative studies on 1064\u2010nm neodymium\u2010yttrium aluminum garnet (<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>d\u2010<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content>) laser and pulsed dye laser (<jats:styled-content style=\"fixed-case\">PDL<\/jats:styled-content>) in treatment of erythemato\u2010telangiectatic rosacea are lacking. Substance (<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>) is implicated in rosacea pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the effect of <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>d\u2010<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser and <jats:styled-content style=\"fixed-case\">PDL<\/jats:styled-content> on erythemato\u2010telangiectatic rosacea, both clinically and immunohistochemically on cutaneous substance (<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>) expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This split\u2010face comparative study included 15 patients with erythemato\u2010telangiectatic rosacea treated on the right side with <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>d\u2010<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser and on the left side with <jats:styled-content style=\"fixed-case\">PDL<\/jats:styled-content>: three sessions, 4\u00a0weeks apart. Evaluation of the patients was done using erythema and telangiectasia grading scores, patient's self\u2010assessment, physicians' clinical assessment of the patient, and immunohistochemical assessment of substance (<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One month after the three laser sessions, excellent response was achieved in 73.3% of patients after <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>d\u2010<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> and in 53.3% of patients after <jats:styled-content style=\"fixed-case\">PDL<\/jats:styled-content> with significantly lower substance (<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>) concentration after <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>d\u2010<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser than after <jats:styled-content style=\"fixed-case\">PDL<\/jats:styled-content>. Positive correlations were found between the decrease in erythema and telangiectasia grading scores and the decrease in substance (<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>) concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>d\u2010<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser and <jats:styled-content style=\"fixed-case\">PDL<\/jats:styled-content> appears to be safe and effective measures in treatment of erythemato\u2010telangiectatic rosacea. Both types of laser decrease the concentration of substance (<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>) in the skin. This effect is more pronounced with <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>d\u2010<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12048","type":"journal-article","created":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T04:41:59Z","timestamp":1378096919000},"page":"187-194","source":"Crossref","is-referenced-by-count":29,"title":["Neodymium\u2010yttrium aluminum garnet laser versus pulsed dye laser in erythemato\u2010telangiectatic rosacea: comparison of clinical efficacy and effect on cutaneous substance (<scp>P<\/scp>) expression"],"prefix":"10.1111","volume":"12","author":[{"given":"Samar Abdallah M","family":"Salem","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Medicine Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nermeen SA","family":"Abdel Fattah","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Medicine Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah MA","family":"Tantawy","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Medicine Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafissa MA","family":"El\u2010Badawy","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser A","family":"Abd El\u2010Aziz","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Faculty of Medicine Ain Shams University Cairo 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