{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T17:31:06Z","timestamp":1780680666543,"version":"3.54.1"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Phosphatidylcholine (<jats:styled-content style=\"fixed-case\">PPC<\/jats:styled-content>) and sodium deoxycholate (<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>) injections have been used cosmetically to reduce localized fat, but to date, few studies have addressed the histological effect of human fat tissue following injections of <jats:styled-content style=\"fixed-case\">PPC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>. We injected <jats:styled-content style=\"fixed-case\">PPC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> mixed with normal saline into the patient's abdominal area. Examinations of postinjection tissue revealed marked changes within the subcutaneous fat. We observed important microscopic evidence of substitution of fat by fibrosis, marked inflammatory infiltration with microabscess formation in the dermis, and septal and lobular panniculitis with thick fibrous septa. Fat necrosis with microcalcification and cyst formation were observed in the subcutaneous fat. Fibroid necrosis with extravasation was noted in the small vessels around fat necrosis. Therefore, careful use of <jats:styled-content style=\"fixed-case\">PPC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> is recommended when patients want to cosmetically reduce localized fat.<\/jats:p>","DOI":"10.1111\/jocd.12053","type":"journal-article","created":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T04:41:59Z","timestamp":1378096919000},"page":"240-243","source":"Crossref","is-referenced-by-count":23,"title":["Histological changes after treatment for localized fat deposits with phosphatidylcholine and sodium deoxycholate"],"prefix":"10.1111","volume":"12","author":[{"given":"Eun\u2010Jung","family":"Park","sequence":"first","affiliation":[{"name":"Department of Family Medicine Cheil General Hospital and Women's Healthcare Center, Kwandong University, College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye\u2010Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Cheil General Hospital and Women's Healthcare Center, Kwandong University, College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Clinic M infirmary Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Jin","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Cheil General Hospital and Women's Healthcare Center, Kwandong University, College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/074880688700400403"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-003-3033-y"},{"key":"e_1_2_5_4_1","first-page":"511","article-title":"Phosphatidylcholine in the treatment of localized fat","volume":"2","author":"Hexsel D","year":"2003","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00651.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30305.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2005.00211.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asj.2005.07.009"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-005-0170-5"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200608000-00007"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30114.x"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12053","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12053","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T08:07:45Z","timestamp":1696234065000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/jocd.12053"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12053","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}