{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T17:51:56Z","timestamp":1785261116422,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T00:00:00Z","timestamp":1386115200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To demonstrate safety with the use of polymethyl methacrylate (<jats:styled-content style=\"fixed-case\">PMMA<\/jats:styled-content>) microspheres in the infraorbital eyelid area using a deliberate conservative injection in the treatment of rhytids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective case series of 289 patients in an outpatient cosmetic dermatology clinic evaluated and treated by one senior provider (<jats:styled-content style=\"fixed-case\">NM<\/jats:styled-content>) of infraorbital rhytids with <jats:styled-content style=\"fixed-case\">PMMA<\/jats:styled-content> from <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2010 to <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arch 2011. Statistical analysis was performed for race, skin type, history of hypertrophic scar, autoimmunity, history of \u201csensitive skin\u201d and history of prior procedures such as prior facelift, rhinoplasty, and blepharoplasty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred ninety\u2010one patients underwent at least 1\u20136 injections of <jats:styled-content style=\"fixed-case\">PMMA<\/jats:styled-content> microspheres into bilateral under eye area. Early complications were edema and ecchymosis. Late complications were identified in 4 of 289 patients who developed small granulomas. All patients who developed granulomas had had a previous lower blepharoplasty (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.00). A history of \u201csensitive skin\u201d was approaching statistical significance (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.15).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study has shown that <jats:styled-content style=\"fixed-case\">PMMA<\/jats:styled-content> microsphere injection is a safe subdermal technique in the correction of infraorbital rhytids. Safety was demonstrated in 289 patients with only 4 minor complications of small lateral granuloma which all resolved within 4\u00a0weeks after intralesion triamcinolone injection. However, this is an off\u2010label use of a permanent filler not approved for use in the infraorbits and significant caution must be taken with full disclosure to the patient leading to informed consent. Caution in <jats:styled-content style=\"fixed-case\">PMMA<\/jats:styled-content> microsphere injection should be given in the patient with prior blepharoplasty. The advantage of <jats:styled-content style=\"fixed-case\">PMMA<\/jats:styled-content> microsphere is that the result seems to be predictable and natural.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12065","type":"journal-article","created":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T15:00:05Z","timestamp":1386169205000},"page":"275-280","source":"Crossref","is-referenced-by-count":21,"title":["Novel use of polymethyl methacrylate (<scp>PMMA<\/scp>) microspheres in the treatment of infraorbital rhytids"],"prefix":"10.1111","volume":"12","author":[{"given":"Nasrin","family":"Mani","sequence":"first","affiliation":[{"name":"La Jolla Cosmetic Laser Clinic La Jolla CA USA"},{"name":"California Retina Associates Chula Vista CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"McLeod","sequence":"additional","affiliation":[{"name":"La Jolla Cosmetic Laser Clinic La Jolla CA USA"},{"name":"La Jolla Cosmetic Laser Clinic San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell B","family":"Sauder","sequence":"additional","affiliation":[{"name":"Division of Dermatology University of Ottawa Ottawa ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel N","family":"Sauder","sequence":"additional","affiliation":[{"name":"Division of Dermatology University Hospital at Princeton Princeton NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella R","family":"Bothwell","sequence":"additional","affiliation":[{"name":"Department of Surgery and Division of Otolaryngology University of California San Diego San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.10.007"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfaci.11.1.6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182362c63"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01262.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfacial.2011.48"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-009-9413-1"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33365.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01551.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1090820X12442372"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)80090-9"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1220651"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12065","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T08:16:06Z","timestamp":1696234566000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/jocd.12065"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12065","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}