{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:36Z","timestamp":1787015496109,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T00:00:00Z","timestamp":1402272000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Summary<\/jats:title>\n \n Introduction<\/jats:title>\n \n Skin photoaging is the consequence of solar\n UV<\/jats:styled-content>\n exposure, and\n DNA<\/jats:styled-content>\n damage is an important part of this process. The objective of the current work was to demonstrate that\n in vitro<\/jats:italic>\n skin models can be utilized to confirm that\n DNA<\/jats:styled-content>\n damage protection is provided by sunscreens.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Skin equivalents were exposed to full\u2010spectrum\n UV<\/jats:styled-content>\n light administered with a standard research solar simulator with and without pre\u2010application of sunscreen. Cyclopyrimidine dimer (\n CPD<\/jats:styled-content>\n ) and sunburn cell (\n SBC<\/jats:styled-content>\n ) formation as well as\n CPD<\/jats:styled-content>\n quantitation were evaluated to determine\n DNA<\/jats:styled-content>\n damage protection provided by the sunscreen.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Marked decreases in both\n CPD<\/jats:styled-content>\n s and\n SBC<\/jats:styled-content>\n s were observed when sunscreen was applied prior to\n UV<\/jats:styled-content>\n exposure.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Sunscreen application prior to full\u2010spectrum solar\n UV<\/jats:styled-content>\n exposure protects\n DNA<\/jats:styled-content>\n from photodamage measured by\n CPD<\/jats:styled-content>\n and\n SBC<\/jats:styled-content>\n formation. This can be expected to lessen the risk of photoaging and malignant transformation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.12087","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T06:30:00Z","timestamp":1402295400000},"page":"99-102","source":"Crossref","is-referenced-by-count":8,"title":["DNA<\/scp>\n photoprotection conveyed by sunscreen"],"prefix":"10.1111","volume":"13","author":[{"given":"Charlene","family":"DeHaven","sequence":"first","affiliation":[{"name":"Innovative Skincare Burbank California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J","family":"Hayden","sequence":"additional","affiliation":[{"name":"MatTek Corp. Ashland Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Armento","sequence":"additional","affiliation":[{"name":"MatTek Corp. Ashland Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Oldach","sequence":"additional","affiliation":[{"name":"MatTek Corp. Ashland Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.120-a308"},{"key":"e_1_2_5_3_1","first-page":"127","article-title":"The sunburn cell","volume":"4","author":"Young AR","year":"1987","journal-title":"Photodermatol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/b108291d"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1pp05232b"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1pp05144j"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2009.07.021"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.8465"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400413"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.1996.40318.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.08.050"},{"key":"e_1_2_5_12_1","first-page":"207","article-title":"Engineering skin to study human disease\u2014tissue models for cancer biology and wound repair","volume":"103","author":"Garlick JA","year":"2007","journal-title":"Adv Biochem Eng Biotechnol"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1993.tb00043.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700014"},{"key":"e_1_2_5_15_1","unstructured":"News Releases. Sunscreen remains a safe effective form of sun protection. Schaumburg IL. 16 May 2012.www.aad.org\/dermatology-a-to-a\/health-and-beauty\/general-skin-care\/sun-protection. AAD website \u00a92013."},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi367"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12087","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12087","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T10:22:36Z","timestamp":1696242156000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/jocd.12087"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12087","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}