{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:19:38Z","timestamp":1785536378710,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T00:00:00Z","timestamp":1416182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:label\/><jats:p>The Safety of Microfocused Ultrasound with Visualization (<jats:styled-content style=\"fixed-case\">MFU<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>) has been well established in both controlled clinical studies and in clinical use, showing only mild and transient anticipated side effects and only rare unanticipated adverse events (<jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s). This publication discusses the safety profile of <jats:styled-content style=\"fixed-case\">MFU<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">V<\/jats:styled-content> based on data from a variety of sources. Reports of side effects and <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s were obtained from published peer\u2010reviewed medical literature, clinical studies, in\u2010market use reports (<jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s reported to the manufacturer), and retrospective chart reviews of patient treatments. Events that were typical included tenderness, redness, and slight edema. Rare events included bruising, welting, and nerve\u2010related effects (paresthesia and paresis). Rare incidence of surface thermal effects was seen in some cases where improper technique was used. In all cases where the device was uses properly, the safety events reported tended to be transient, mild in nature, and resolved without sequelae. In general, unexpected and rare <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s could be attributed to incorrect treatment technique or classified as unrelated to <jats:styled-content style=\"fixed-case\">MFU<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">V<\/jats:styled-content> treatment. Side effects that do occur are generally mild and transient in nature. <jats:styled-content style=\"fixed-case\">MFU<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">V<\/jats:styled-content> consistently allows for safe treatment when correct treatment technique is used.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12111","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T05:26:21Z","timestamp":1416201981000},"page":"329-335","source":"Crossref","is-referenced-by-count":32,"title":["Review of the safety profile for microfocused ultrasound with visualization"],"prefix":"10.1111","volume":"13","author":[{"given":"Thomas M","family":"Hitchcock","sequence":"first","affiliation":[{"name":"Ulthera, Inc. 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