{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:01:39Z","timestamp":1794009699383,"version":"4.8.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T00:00:00Z","timestamp":1438905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are numerous methods currently available for the management of xanthelasma. These include surgical excision, laser ablation using a variety of lasers and chemical cauterization. However, each method of treatment is associated with particular limitations and side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the clinical efficacy and tolerability of different concentrations of topical trichloroacetic acid (TCA) <jats:italic>vs<\/jats:italic>. carbon dioxide laser in the treatment of patients with xanthelasma palpebrarum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty patients with xanthelasma palpebrarum were classified into four groups, treated by TCA 35%, 50%, 70%, and CO<jats:sub>2<\/jats:sub> laser, respectively. Lipid profile was estimated for all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both TCA peeling 70% and carbon dioxide laser ablation showed more significant clinical efficacy and tolerability with least number of sessions in the treatment of xanthelasma palpebrarum than 50% and 35% TCA peeling. Post\u2010therapy erythema and hypopigmentation were more with TCA 70%. Post\u2010therapy hyperpigmentation was more with TCA (50%). There was a significant improvement in patients with normal lipid profile than those with abnormal profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both TCA peeling 70% and carbon dioxide laser ablation are highly effective and well tolerated with least number of sessions in the treatment of xanthelasma palpebrarum.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12148","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:13:54Z","timestamp":1438942434000},"page":"209-215","source":"Crossref","is-referenced-by-count":30,"title":["Assessment of efficacy and tolerability of different concentrations of trichloroacetic acid <i>vs<\/i>. carbon dioxide laser in treatment of xanthelasma palpebrarum"],"prefix":"10.1111","volume":"14","author":[{"given":"Basma","family":"Mourad","sequence":"first","affiliation":[{"name":"Department of Dermatology &amp; Venereology Faculty of medicine Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia H.","family":"Elgarhy","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Venereology Faculty of medicine Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba\u2010Alla","family":"Ellakkawy","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Venereology Faculty of medicine Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nageh","family":"Elmahdy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Faculty of Pharmacy Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02913335"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2340\/0001555576107110","article-title":"Normolipidemic xanthelasma palpebrarum: lipid composition, cholesterol metabolism in monocyte\u2010derived macrophages, and plasma lipid peroxidation","volume":"76","author":"Bergman R","year":"1996","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e3182873d13"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2011-130443"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200210000-00016"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03818.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630500475708"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:INTE.0000018523.55861.6c"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08194.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asj.2004.07.008"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.58519"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2013.777153"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30061.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1987.tb00512.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199312000-00005"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2013.40.4.380"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(1999)24:2<122::AID-LSM7>3.0.CO;2-6"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1986.01660230045008"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.10.033"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e3181aa9a1f"},{"key":"e_1_2_5_22_1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0094-1298(20)30933-0","article-title":"Trichloroacetic acid and other non\u2010phenol peels","volume":"19","author":"Rubin MG","year":"1992","journal-title":"Clin Plast Surg"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1998.tb04297.x"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12148","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12148","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T22:55:01Z","timestamp":1696200901000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,7]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/jocd.12148"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12148","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,7]]}}}