{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:36:31Z","timestamp":1756463791737},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Androgenetic alopecia (AGA<\/jats:styled-content>) or common baldness is the most prevalent form of hair loss in males. Familial predisposition has been recognized, and heritability estimated in monozygotic twins suggests an important genetic predisposition. Several studies indicate that the numbers of CAG<\/jats:styled-content>\/GGC<\/jats:styled-content> repeats in exon 1 of the androgen receptor gene (AR<\/jats:styled-content>)<\/jats:italic> maybe associated with AGA<\/jats:styled-content> susceptibility.<\/jats:p><\/jats:sec>Aims<\/jats:title>To investigate a possible correlation between AR<\/jats:styled-content><\/jats:italic> CAG<\/jats:styled-content>\/GGC<\/jats:styled-content> haplotypes and the presence or not of alopecia in sibships with two or more brothers among them at least one of them has AGA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Patients\/Methods<\/jats:title>Thirty\u2010two trios including an alopecic man, one brother alopecic or not, and their mother were enrolled. Sanger sequencing of the exon 1 of the AR<\/jats:styled-content><\/jats:italic> gene was conducted to ascertain the number of CAG<\/jats:styled-content>\/GGC<\/jats:styled-content> repeats in each individual. Heterozygous mother for the CAG<\/jats:styled-content>\/GGC<\/jats:styled-content> haplotypes was an inclusion criterion to analyze the segregation haplotype patterns in the family. Concordance for the number of repeats and AGA<\/jats:styled-content> among brothers was evaluated using kappa coefficient and the probability of association in the presence of genetic linkage between CAG<\/jats:styled-content> and GGC<\/jats:styled-content> repeats and AGA<\/jats:styled-content> estimated by means of the family\u2010based association test (FBAT<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>The median for the CAG<\/jats:styled-content> and GGC<\/jats:styled-content> repeats in the AR<\/jats:styled-content><\/jats:italic> is similar to that reported in other populations. The CAG<\/jats:styled-content>\/GGC<\/jats:styled-content> haplotypes were less polymorphic than that reported in other studies, especially due to the GGC<\/jats:styled-content> number of repeats found. Kappa<\/jats:italic> coefficient resulted in a concordance of 37.3% (IC<\/jats:styled-content> 95%, 5.0\u201369.0%) for the AGA<\/jats:styled-content> phenotype and identical CAG<\/jats:styled-content>\/GGC<\/jats:styled-content> haplotypes. There was no evidence of linkage disequilibrium.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our results do not confirm a possible correlation or linkage disequilibrium between the CAG<\/jats:styled-content>\/GGC<\/jats:styled-content> haplotypes of the AR<\/jats:styled-content><\/jats:italic> gene and androgenetic alopecia in Mexican brothers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12159","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T20:48:00Z","timestamp":1436906880000},"page":"268-273","source":"Crossref","is-referenced-by-count":2,"title":["Lack of concordance and linkage disequilibrium among brothers for androgenetic alopecia and CAG<\/scp>\/GGC<\/scp> haplotypes of the androgen receptor gene in Mexican families"],"prefix":"10.1111","volume":"14","author":[{"given":"Jazm\u00edn","family":"Arteaga\u2010V\u00e1zquez","sequence":"first","affiliation":[{"name":"Departamento de Gen\u00e9tica Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n \u201cSalvador Zubir\u00e1n\u201d M\u00e9xico D.F. M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda A.","family":"L\u00f3pez\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n \u201cSalvador Zubir\u00e1n\u201d M\u00e9xico D.F. M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yevgeniya","family":"Svyryd","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n \u201cSalvador Zubir\u00e1n\u201d M\u00e9xico D.F. M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osvaldo M.","family":"Mutchinick","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n \u201cSalvador Zubir\u00e1n\u201d M\u00e9xico D.F. 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