{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T21:31:22Z","timestamp":1772659882141,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T00:00:00Z","timestamp":1438041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Androgenetic alopecia (AGA<\/jats:styled-content>) is the commonest form of hair loss in men.<\/jats:bold> Alopecia areata (AA<\/jats:styled-content>) is an organ\u2010specific autoimmune disease.<\/jats:bold> Studies revealed that Dickkopf 1 (DKK<\/jats:styled-content>\u20101), a powerful suppressor of the Wnt\/\u03b2<\/jats:italic>\u2010catenin signaling pathway,<\/jats:bold> induced anagen\u2010to\u2010catagen transition in mice. Moreover, in\u00a0vitro<\/jats:italic> studies suggested that DKK<\/jats:styled-content>\u20101 played a role in dihydrotestosterone (DHT<\/jats:styled-content>)\u2010induced balding.<\/jats:p><\/jats:sec>Aim<\/jats:title>To evaluate the tissue levels of DKK<\/jats:styled-content>\u20101 in patients with AGA<\/jats:styled-content> and AA<\/jats:styled-content>, to assess its possible role as a pathogenetic mechanism in both disorders.<\/jats:bold><\/jats:p><\/jats:sec>Methods<\/jats:title>This study included 24 patients with AGA<\/jats:styled-content>, 31 patients with AA<\/jats:styled-content>, and 33 healthy controls. Scalp biopsies were taken from all participants for the detection of tissue DKK<\/jats:styled-content>\u20101 levels.<\/jats:p><\/jats:sec>Results<\/jats:title>Tissue DKK<\/jats:styled-content>\u20101 levels were significantly higher in patients with AGA<\/jats:styled-content> than in controls (P<\/jats:italic>\u00a0=\u00a00.000) as well as in patients with AA<\/jats:styled-content> than in controls (P<\/jats:italic>\u00a0=\u00a00.001). In addition, they were significantly higher in patients with AGA<\/jats:styled-content> than in patients with AA<\/jats:styled-content> (P<\/jats:italic>\u00a0=\u00a00.000). DKK<\/jats:styled-content>\u20101 was higher in male than in female patients with AGA<\/jats:styled-content>. DKK<\/jats:styled-content>\u20101 was negatively correlated with disease duration in AGA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In conclusion, this study suggests an important role for DKK<\/jats:styled-content>\u20101 in the pathogenesis of AGA<\/jats:styled-content> and AA<\/jats:styled-content> through documenting higher tissue DKK<\/jats:styled-content>\u20101 levels in patients with both hair disorders compared to controls and suggests that DKK<\/jats:styled-content>\u20101 may be a promising therapeutic target for these hair diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12171","type":"journal-article","created":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T10:04:52Z","timestamp":1438077892000},"page":"10-15","source":"Crossref","is-referenced-by-count":23,"title":["Assessment of tissue levels of dickkopf\u20101 in androgenetic alopecia and alopecia areata"],"prefix":"10.1111","volume":"15","author":[{"given":"Marwa M T","family":"Fawzi","sequence":"first","affiliation":[{"name":"Department of Dermatology Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara B","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Dermatology Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olfat G.","family":"Shaker","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwah A","family":"Saleh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Cairo University Cairo 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