{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T10:41:29Z","timestamp":1776854489872,"version":"3.51.2"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T00:00:00Z","timestamp":1446163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Retinoids (<jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>), alpha\u2010hydroxy acids (<jats:styled-content style=\"fixed-case\">AHA<\/jats:styled-content>), and salicylic acid (<jats:styled-content style=\"fixed-case\">BHA<\/jats:styled-content>) treat acne through differing mechanisms of action. It is theorized that optimal improvement can be achieved by combining the <jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>\u2010induced normalization of cellular differentiation, <jats:styled-content style=\"fixed-case\">AHA<\/jats:styled-content>\u2010induced exfoliation in hydrophilic areas, and <jats:styled-content style=\"fixed-case\">BHA<\/jats:styled-content>\u2010induced exfoliation in lipophilic areas. <jats:styled-content style=\"fixed-case\">AHA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content> have been combined in a bioengineered molecule (<jats:styled-content style=\"fixed-case\">AHA<\/jats:styled-content> retinoid conjugate, or <jats:styled-content style=\"fixed-case\">AHA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>) delivering both lactic acid (<jats:styled-content style=\"fixed-case\">AHA<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content> in a manner reducing retinoid\u2010associated irritation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate efficacy and tolerability of a twice\u2010daily, three\u2010product skincare regimen using <jats:styled-content style=\"fixed-case\">AHA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content> in combination with <jats:styled-content style=\"fixed-case\">BHA<\/jats:styled-content> for patients with acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 27 women (age range 20\u201358 years, mean 37.81 \u00b1 10.04 years) with mild\u2010to\u2010moderate acne used a 3\u2010product regimen consisting of a twice\u2010daily cleanser and topical serum (0.1% <jats:styled-content style=\"fixed-case\">AHA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>, 2% salicylic acid, and 10.4% l\u2010lactic acid), with broad\u2010spectrum <jats:styled-content style=\"fixed-case\">SPF<\/jats:styled-content> 50+ sunscreen as needed, over an 8\u2010week period. Counts were made at baseline, week 4, and week 8 of total inflammatory (papules, pustules) and noninflammatory (open comedones, closed comedones) lesions. Dryness, stinging, and other secondary endpoints were rated on a 0\u20135 scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Statistically significant reduction in inflammatory and noninflammatory lesion counts (<jats:italic>P<\/jats:italic> = 0.006 and <jats:italic>P<\/jats:italic> = 0.015, respectively) was noted at 4 weeks. Improvement continued into week 8 with highly significant (<jats:italic>P<\/jats:italic> &lt; 0.001) reductions in both lesion counts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The topical combination of lactic acid, <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">AHA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content> produced acne improvement after 4 weeks with continuing cumulative improvement at 8 weeks. <jats:styled-content style=\"fixed-case\">AHA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content> represents a new molecule combining several mechanisms of action to achieve acne improvement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12190","type":"journal-article","created":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T07:29:18Z","timestamp":1446190158000},"page":"36-42","source":"Crossref","is-referenced-by-count":19,"title":["Novel retinoid ester in combination with salicylic acid for the treatment of acne"],"prefix":"10.1111","volume":"15","author":[{"given":"Zoe","family":"Draelos","sequence":"first","affiliation":[{"name":"Dermatology Consulting Services High Point NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Lewis","sequence":"additional","affiliation":[{"name":"US CosmeceuTechs LLC Richmond VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"McHugh","sequence":"additional","affiliation":[{"name":"US CosmeceuTechs LLC Richmond VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Elizabeth Arden, Inc. New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lavinia","family":"Popescu","sequence":"additional","affiliation":[{"name":"Elizabeth Arden, Inc. 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