{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:16:20Z","timestamp":1776917780541,"version":"3.51.2"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T00:00:00Z","timestamp":1446595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["#UL1 TR000002"],"award-info":[{"award-number":["#UL1 TR000002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The reproducible evaluation of facial redness is critical to the assessment of erythematotelangiectatic rosacea. Assessments have typically focused on the use of photography with the use of semi\u2010quantitative grading scales based on evaluator rating. However, few studies have utilized computer\u2010based algorithms to evaluate facial redness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this clinical study was to assess whether there is correlation between clinical grading of facial redness to the assessment of a quantitative computer\u2010based facial modeling and measurement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>In this prospective study, a set of high\u2010resolution facial photographs and cross\u2010polarized subsurface photographs for erythema detection were obtained for 31 study participants. A computer algorithm was then utilized to detect and quantify facial redness in the photographs and compare this to semi\u2010quantitative evaluator\u2010based grading for facial redness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a strong correlation between computer\u2010based cross\u2010polarized subsurface erythema quantification and clinical grading for redness intensity (Clinical Erythema Assessment), redness distribution, and overall redness severity (Modified Clinical Erythema Assessment).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall, facial redness measurements by facial imaging and computer analysis correlated well to clinical grading scales for both redness intensity and distribution. Future studies should incorporate facial modeling and analysis tools for assessments in clinical studies to introduce greater objectivity and quantitative analysis in facial erythema\u2010based analyses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12191","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T05:38:47Z","timestamp":1446615527000},"page":"43-48","source":"Crossref","is-referenced-by-count":22,"title":["The use of facial modeling and analysis to objectively quantify facial redness"],"prefix":"10.1111","volume":"15","author":[{"given":"Negar","family":"Foolad","sequence":"first","affiliation":[{"name":"Department of Dermatology University of California \u2013 Davis Sacramento CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Prakash","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California \u2013 Davis Sacramento CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian Y","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California \u2013 Davis Sacramento CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faranak","family":"Kamangar","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California \u2013 Davis Sacramento CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinlu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Statistics University of California \u2013 Davis Davis CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin\u2010Shang","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Biostatistics Department of Public Health Sciences University of California \u2013 Davis Sacramento CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raja K","family":"Sivamani","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California \u2013 Davis Sacramento CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690030091015"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120625"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.05.044"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12881"},{"key":"e_1_2_6_6_1","first-page":"650","article-title":"Efficacy and safety of once\u2010daily topical brimonidine tartrate gel 0.5% for the treatment of moderate to severe facial erythema of rosacea: results of two randomized, double\u2010blind, and vehicle\u2010controlled pivotal studies","volume":"12","author":"Fowler J","year":"2013","journal-title":"J Drugs 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