{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T21:23:02Z","timestamp":1783200182680,"version":"3.54.6"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T00:00:00Z","timestamp":1462147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cytokeratins (<jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>) belong to the family of intermediate filament proteins, and among them specific epithelial keratins are considered markers for stem cells activation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aims to investigate the expression of <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>15 and <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>19 as possible stem cell markers in vitiligo during phototherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was conducted on vitiligo patients receiving narrow\u2010band ultraviolet therapy. Immunohistochemical staining for <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>15 and <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>19 was carried out, and clinical follow\u2010up continued for 4 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 28 patients, <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>15 expression was demonstrated in 17 cases (61%) while <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>19 expression was demonstrated in 11 cases (39%). Cells expressing positive staining were demonstrated in follicular and interfollicular epithelium. Expression was clearly demonstrated in patients younger than 20 years old, with shorter disease duration, with disease stability, and with normally pigmented hairs. Expression of cytokeratins was significantly correlated to improvement of vitiligo lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>15 and <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>19 are expressed in vitiligo during <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> repigmentation in the follicular and interfollicular epithelium. This expression of cytokeratins was significantly correlated to improvement and can be considered valuable tool to monitor stem cells stimulation for the sake of the repigmentation process in vitiligo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12223","type":"journal-article","created":{"date-parts":[[2016,5,3]],"date-time":"2016-05-03T10:52:31Z","timestamp":1462272751000},"page":"312-317","source":"Crossref","is-referenced-by-count":3,"title":["Epithelial expression of cytokeratins 15 and 19 in vitiligo"],"prefix":"10.1111","volume":"15","author":[{"given":"Fatma Y","family":"Saleh","sequence":"first","affiliation":[{"name":"Department of Dermatology, STDs and Andrology Faculty of Medicine Minia University Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif S","family":"Awad","sequence":"additional","affiliation":[{"name":"Department of Dermatology, STDs and Andrology Faculty of Medicine Minia University Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada A","family":"Nasif","sequence":"additional","affiliation":[{"name":"Department of Dermatology, STDs and Andrology Faculty of Medicine Minia University Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christein","family":"Halim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, STDs and Andrology Faculty of Medicine Minia University Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01139.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12304"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.322"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.09.022"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/416854a"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1959.154"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2008.00456.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.111.1.153"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2009.48"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/29.12.7033366"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.254"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12034"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90251-K"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5457.1431"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/35102160"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00208-2"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26043"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22275"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00535.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2031"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12541084"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03233.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099593"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12082"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2012.01.012"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2004.00221.x"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12223","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12223","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T11:58:46Z","timestamp":1696161526000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,2]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/jocd.12223"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12223","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,2]]}}}