{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:35:50Z","timestamp":1785306950199,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T00:00:00Z","timestamp":1462492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Alopecia areata (AA<\/jats:styled-content>) is a frequent autoimmune disease, the pathogenesis of which is still unknown. Androgenetic alopecia (AGA<\/jats:styled-content>) is a noncicatricial type of patterned hair loss. Expression of vitamin D receptors (VDR<\/jats:styled-content>s) on keratinocytes is essential for maintenance of normal hair cycle, especially anagen initiation.<\/jats:p><\/jats:sec>Objective<\/jats:title>To assess VDR<\/jats:styled-content>s in the skin and blood of AA<\/jats:styled-content> and AGA<\/jats:styled-content> patients, in order to evaluate their possible role in these hair diseases.<\/jats:p><\/jats:sec>Methods<\/jats:title>This study recruited 20 patients with AA<\/jats:styled-content>, 20 patients with AGA<\/jats:styled-content>, and 20 healthy controls. Blood samples and lesional scalp biopsies were taken from all participants for detection of VDR<\/jats:styled-content> levels.<\/jats:p><\/jats:sec>Results<\/jats:title>Serum and tissue VDR<\/jats:styled-content> levels were lower in AA<\/jats:styled-content> as well as AGA<\/jats:styled-content> patients when compared to controls (P<\/jats:italic> = 0.000). Serum and tissue VDR<\/jats:styled-content> were positively correlated in each group. Tissue VDR<\/jats:styled-content> was significantly lower in female patients with AA<\/jats:styled-content> than males (P<\/jats:italic> = 0.046) although serum and tissue VDR<\/jats:styled-content> levels were significantly higher in female AGA<\/jats:styled-content> patients than males (P<\/jats:italic> = 0.004).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This study suggests an important role for VDR<\/jats:styled-content> in the pathogenesis of AA<\/jats:styled-content> and AGA<\/jats:styled-content> through documenting lower serum and tissue VDR<\/jats:styled-content> levels in AA<\/jats:styled-content> and AGA<\/jats:styled-content> patients in comparison with controls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12224","type":"journal-article","created":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T08:49:20Z","timestamp":1462524560000},"page":"318-323","source":"Crossref","is-referenced-by-count":32,"title":["Assessment of vitamin D receptors in alopecia areata and androgenetic alopecia"],"prefix":"10.1111","volume":"15","author":[{"given":"Marwa M T","family":"Fawzi","sequence":"first","affiliation":[{"name":"Department of Dermatology Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Bahaa","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Dermatology Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shereen Fathi","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Dermatology Department Bolak El Dakror Hospital Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olfat Gamil","family":"Shaker","sequence":"additional","affiliation":[{"name":"Biochemistry Faculty of Medicine Cairo University Cairo 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