{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:25:05Z","timestamp":1790029505958,"version":"4.0.1"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003627","name":"Rural Development Administration","doi-asserted-by":"publisher","award":["PJ01132503"],"award-info":[{"award-number":["PJ01132503"]}],"id":[{"id":"10.13039\/501100003627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"Summary<\/jats:title>\n \n Objective<\/jats:title>\n \n Acne vulgaris is a chronic dermatologic disease with four factors involved in the development of lesions. Treatments need to address as many of these underlying factors as possible in order to reduce acne lesions. As such, purified bee venom (\n PBV<\/jats:styled-content>\n \u2122<\/jats:sup>\n ) serum is an attractive therapeutic option for acne, but little data exist on the efficacy of this treatment strategy.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this prospective, noncomparative study, 30 subjects having mild\u2010to\u2010moderate acne vulgaris were enrolled and treated with\n PBV<\/jats:styled-content>\n \u2122<\/jats:sup>\n serum twice daily for a period of 6 weeks. Clinical evaluation of lesions by expert visual grading and image analysis were made at weeks 0 (baseline), 3, and 6.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The average visual acne grade of all volunteers significantly improved with the\n PBV<\/jats:styled-content>\n \u2122<\/jats:sup>\n serum treatment at weeks 3 (\n P<\/jats:italic>\n < 0.05) and 6 (\n P<\/jats:italic>\n < 0.001) when compared with the baseline grade at week 0. In addition, there was a mean percent improvement of 8.6% and 52.3% in acne grade observed after 3 and 6 weeks of\n PBV<\/jats:styled-content>\n \u2122<\/jats:sup>\n serum use, with 20% and 77% of the subjects showing improvement, respectively, when compared with baseline. Moreover, the subjects showed improvement in open comedones, closed comedones, papules, pustules, and nodules after 3 and 6 weeks of\n PBV<\/jats:styled-content>\n \u2122<\/jats:sup>\n serum use.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Six weeks of treatment with\n PBV<\/jats:styled-content>\n \u2122<\/jats:sup>\n serum was found to be effective in the treatment of mild\u2010to\u2010moderate acne vulgaris, with no incidence of serious side effects or irritation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.12227","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T14:56:54Z","timestamp":1464101814000},"page":"324-329","source":"Crossref","is-referenced-by-count":22,"title":["Evaluation of anti\u2010acne property of purified bee venom serum in humans"],"prefix":"10.1111","volume":"15","author":[{"given":"Sang Mi","family":"Han","sequence":"first","affiliation":[{"name":"Department of Agricultural Biology National Institute of Agricultural Science Wanju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sok Cheon","family":"Pak","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences Charles Sturt University Bathurst NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Mee","family":"Nicholls","sequence":"additional","affiliation":[{"name":"Level 13 Manuka Doctor Limited Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Macfarlane","sequence":"additional","affiliation":[{"name":"Level 13 Manuka Doctor Limited Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,24]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"636","article-title":"Evidence\u2010based review: fixed\u2010combination therapy and topical retinoids in the treatment of acne","volume":"10","author":"Webster GF","year":"2011","journal-title":"J Drugs Dermatol"},{"issue":"5","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jdv.13186","article-title":"From new findings in acne pathogenesis to new approaches in treatment","volume":"29","author":"Gollnick H","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.19828"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.63.8.3158-3165.1995"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087011"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2015.2180"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2014.1933"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1979.04010050005003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.08.001"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.75"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2012.698402"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12227","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12227","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12227","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.12227","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T07:58:20Z","timestamp":1696147100000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,24]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/jocd.12227"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12227","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,24]]}}}