{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T03:44:46Z","timestamp":1775447086282,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T00:00:00Z","timestamp":1465171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne in adult women is a frequent hard\u2010to\u2010manage disease with many relapse cases. It mostly interferes with the quality of life of patients, bringing them major metabolic and social losses. As androgenic hormones play a very important role in the acne pathogenesis, the early diagnosis of hyperandrogenic states is very useful for the proper evaluation of each patient and for a better choice of therapeutic management. Defining a pattern for laboratory profile analysis is important for the control of relapses of acne breakouts in adult women, which lately has been the aim of many published studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To establish the relation between 3 alpha\u2010diol G levels and acne in female patients with normal androgenic status without menstrual dysfunctions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>The evaluation of serum 3 alpha\u2010androstanediol glucuronide levels through an enzymatic immunoassay method (Androstanediol Glucuronide <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> Kit) for a direct quantitative measurement in 26 patients with grade <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> acne, ages ranging from 13 to 50.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the analyzed patients, 83% had grade <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> acne, and among this total, 60% were aged 14 or over. According to age, 12 studied patients showed serum 3 alpha\u2010diol G levels within normal range and 11 patients had increased levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A total of 60% of adult women with acne present increased levels of androgens and among those with normal levels and without menstrual dysfunctions, 50% show an increase in 3 alpha\u2010diol G. Therefore, a pharmacological approach with anti\u2010androgenic drugs for acne therapy in most of these patients is advisable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12232","type":"journal-article","created":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T00:57:02Z","timestamp":1465261022000},"page":"330-334","source":"Crossref","is-referenced-by-count":6,"title":["Acne in adult women and the markers of peripheral 3 alpha\u2010diol G activity"],"prefix":"10.1111","volume":"15","author":[{"given":"Marisa G","family":"Cunha","sequence":"first","affiliation":[{"name":"Disciplina de Dermatologia FMABC Santo Andr\u00e9 SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina P","family":"Martins","sequence":"additional","affiliation":[{"name":"Disciplina de Dermatologia FMABC Santo Andr\u00e9 SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos D'Aparecida","family":"M 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