{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:36Z","timestamp":1787015496127,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T00:00:00Z","timestamp":1466380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      In persistent female acne,\n                      <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>\n                      (polycystic ovarian syndrome) is a common finding. To diagnose\n                      <jats:styled-content style=\"fixed-case\">PCOM<\/jats:styled-content>\n                      (polycystic ovarian morphology), transvaginal \u2013\n                      <jats:styled-content style=\"fixed-case\">USG<\/jats:styled-content>\n                      is required, which is not possible in virginal women. Also, hyperandrogenemia is not consistently reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The aim of the study was to compare the hormonal profile of persistent acne patients with or without\n                      <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>\n                      and to assess the role of\n                      <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                      (antimullerian hormone) in persistent acne patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross\u2010sectional retrospective study of persistent acne patients was undertaken and detailed hormonal assessment and\n                      <jats:styled-content style=\"fixed-case\">USG<\/jats:styled-content>\n                      was undertaken and patients were divided into two group, those with and without\n                      <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>\n                      . The various clinical parameters,\n                      <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                      and other hormonal levels were compared between the two groups of patients. The predictive value of serum\n                      <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                      level was evaluated using the receiver operating characteristic (\n                      <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>\n                      ) curve analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 112 patients of persistent acne, 40 (34.7%) were described as\n                      <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>\n                      . Mean menstrual cycle length, hirsutism, and\n                      <jats:styled-content style=\"fixed-case\">PCOM<\/jats:styled-content>\n                      (polycystic ovarian morphology) were significantly more in the\n                      <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>\n                      group (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .0001).\n                      <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                      was significantly higher in the\n                      <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>\n                      group of acne patients as compared to the group without\n                      <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>\n                      (6.79 \u00b1 2.79\n                      <jats:italic>vs<\/jats:italic>\n                      . 2.69 \u00b1 1.23,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), and an\n                      <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                      value of 3.6 ng\/mL was predictive of\n                      <jats:styled-content style=\"fixed-case\">PCOM<\/jats:styled-content>\n                      . Apart from the\n                      <jats:styled-content style=\"fixed-case\">SHBG<\/jats:styled-content>\n                      levels which were low in both groups (normal range 34.3\u2013147 nmol\/L), no other hormonal level was deranged. The total testosterone levels were in the high\u2010normal range.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                      is a good tool to diagnose\n                      <jats:styled-content style=\"fixed-case\">PCOM<\/jats:styled-content>\n                      in persistent acne patients and can be used as a replacement for\n                      <jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">USG<\/jats:styled-content>\n                      , although it does not correlate with hyperandrogenemia. Low\n                      <jats:styled-content style=\"fixed-case\">SHBG<\/jats:styled-content>\n                      levels were the most common finding in persistent acne patients and could explain the hyperandrogenism seen in patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.12235","type":"journal-article","created":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T04:43:57Z","timestamp":1466397837000},"page":"343-349","source":"Crossref","is-referenced-by-count":10,"title":["The role of antimullerian hormone in the hormonal workup of women with persistent acne"],"prefix":"10.1111","volume":"15","author":[{"given":"Kabir","family":"Sardana","sequence":"first","affiliation":[{"name":"Dermatology Maulana Azad Medical College Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanchal","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Indraprastha Apollo 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