{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T15:50:46Z","timestamp":1709049046914},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T00:00:00Z","timestamp":1470182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"GlaxoSmithKline Consumer Healthcare Ltd"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Acne is a common, chronic skin disease that has both physical and psychological consequences. Over\u2010the\u2010counter products are a treatment option frequently chosen by dermatologists and acne sufferers for reasons of cost or convenience. There are reports that such products can effect rapid resolution in certain lesion parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the short\u2010term effect of a benzoyl peroxide 3% gel on acne lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 5\u2010day, double\u2010blind, randomized clinical trial was conducted among subjects with mild\u2010to\u2010moderate acne. Subjects applied the benzoyl peroxide 3% gel, a salicylic acid 2% gel, or a vehicle gel under supervision once daily for 4 days. Target lesion parameters of swelling, diameter, and erythema were evaluated at various times after the first and subsequent applications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although target lesion parameters showed overall improvement from baseline, the effects of the active treatment gels were not significantly different from those of the vehicle gel at any evaluation. The assessed parameters showed marked variability in target lesion behavior at the subject level over the course of the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this study illustrate the unpredictability of individual acne lesion's responses to therapy and the challenge associated with using these responses to judge short\u2010term treatment efficacy. While rapid acne resolution is desired by patients and consumers, setting realistic expectations for treatment response is critical to encourage compliance and avoid disappointment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12251","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T04:19:45Z","timestamp":1470284385000},"page":"350-357","source":"Crossref","is-referenced-by-count":3,"title":["Five\u2010day study to judge the short\u2010term effect of a benzoyl peroxide 3% gel on acne lesions"],"prefix":"10.1111","volume":"15","author":[{"given":"Zoe Diana","family":"Draelos","sequence":"first","affiliation":[{"name":"Dermatology Consulting Services High Point NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Ertel","sequence":"additional","affiliation":[{"name":"GSK Consumer Health Research Triangle Park NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dror","family":"Rom","sequence":"additional","affiliation":[{"name":"Prosoft Clinical Wayne PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.01.019"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1989.tb00930.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00839.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.4.454"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02768.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2005.05.008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.07.013"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1751-0759-5-11"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.110901"},{"key":"e_1_2_7_11_1","first-page":"285","article-title":"Most common dermatologic conditions encountered by dermatologists and nondermatologists","volume":"94","author":"Wilmer E","year":"2014","journal-title":"Cutis"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.248"},{"key":"e_1_2_7_13_1","first-page":"32","article-title":"Over\u2010the\u2010counter acne treatments: a review","volume":"5","author":"Decker A","year":"2012","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12121"},{"key":"e_1_2_7_15_1","first-page":"55","article-title":"Over\u2010the\u2010counter topical skin products\u2013a common component of skin disease management","volume":"74","author":"Vogel C","year":"2004","journal-title":"Cutis"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017851"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12580"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1982.tb00906.x"},{"key":"e_1_2_7_19_1","first-page":"AB18","article-title":"Fast\u2010acting treatment of mild to moderated acne lesions by a novel 2% salicylic acid microgel complex","volume":"54","author":"Coret C","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.10.052"},{"key":"e_1_2_7_21_1","unstructured":"NAC\/CARUCase Reports. 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Report #4835.2008."},{"key":"e_1_2_7_22_1","first-page":"1382","article-title":"Safety and efficacy of clindamycin phosphate 1.2%\u2010benzoyl peroxide 3% fixed\u2010dose combination gel for the treatment of acne vulgaris: a phase 3, multicenter, randomized, double\u2010blind, active\u2010 and vehicle\u2010controlled study","volume":"10","author":"Eichenfield L","year":"2011","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_7_23_1","first-page":"38","article-title":"How people with acne decide whether their treatment is working","volume":"171","author":"Warburton K","year":"2014","journal-title":"Br J Dermatol"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12724274"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.12.024"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0926-9959.2001.00007.x"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12251","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T11:57:09Z","timestamp":1696161429000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,3]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/jocd.12251"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12251","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,3]]}}}