{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:26:36Z","timestamp":1783117596646,"version":"3.54.6"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T00:00:00Z","timestamp":1470700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Lifes2good, Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Male pattern baldness, or androgenetic alopecia, affects approximately 50% of the adult population and can cause poor self\u2010image, low self\u2010esteem and have a significant negative impact on the quality of life. An oral nutraceutical supplement based on a marine complex formulation has previously been reported to significantly increase the number of terminal hairs in women with thinning hair. <jats:styled-content style=\"fixed-case\">AIMS<\/jats:styled-content>: The objective of this double\u2010blind, placebo\u2010controlled study was to confirm the beneficial effects of a similar marine complex supplement in adult male subjects with thinning hair (Viviscal<jats:sup>\u00ae<\/jats:sup> Man; Lifes2good, Inc., Chicago, IL, USA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Healthy adult male subjects with thinning hair associated with clinically diagnosed male pattern hair loss were enrolled and randomized to receive study drug or placebo twice daily.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At Day 90, subjects indicated a significant improvement in three of six quality of life measures as well as a significant overall improvement in quality of life. After 180 days, significant increases were observed for total hair count, total hair density, and terminal hair density (for each, <jats:italic>P<\/jats:italic> = 0.001). The investigator assessments revealed significant improvements in terminal and vellus hair count and terminal hair density. Hair pull test results were significantly lower (fewer hairs removed) for study drug vs. placebo at Days 90 (<jats:italic>P<\/jats:italic> &lt; 0.05) and 180 (<jats:italic>P<\/jats:italic> &lt; 0.01). There were no reports of treatment\u2010emergent adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study showed for the first time that a dietary supplement containing a marine complex and other ingredients can decrease hair shedding and promote hair growth in men with thinning hair.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12265","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T03:53:14Z","timestamp":1470801194000},"page":"358-366","source":"Crossref","is-referenced-by-count":32,"title":["A 6\u2010month, randomized, double\u2010blind, placebo\u2010controlled study evaluating the ability of a marine complex supplement to promote hair growth in men with thinning hair"],"prefix":"10.1111","volume":"15","author":[{"given":"Glynis","family":"Ablon","sequence":"first","affiliation":[{"name":"Ablon Skin Institute and Research Center Manhattan Beach CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2007.03.004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70223-G"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-013-0010-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2012.24.3.311"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1612"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/030006059101900208"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/030006059202000201"},{"key":"e_1_2_7_9_1","first-page":"144","article-title":"Uso do extrato de protefnas e polissacarfdeos de origem marinha no tratamento da alopecia androgenetica","volume":"53","author":"Pereira JM","year":"1997","journal-title":"Rev Bras Med"},{"key":"e_1_2_7_10_1","first-page":"S15","article-title":"The safety and efficacy of a sustainable marine extract for the treatment of thinning hair: a summary of new clinical research and results from a panel discussion on the problem of thinning hair and current treatments","volume":"14","author":"Hornfeldt CS","year":"2015","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/841570"},{"key":"e_1_2_7_12_1","first-page":"28","article-title":"A double\u2010blind, placebo\u2010controlled study evaluating the efficacy of an oral supplement in women with self\u2010perceived thinning hair","volume":"5","author":"Ablon G","year":"2012","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.171573"},{"key":"e_1_2_7_14_1","first-page":"15","article-title":"A randomized, double\u2010blind, placebo\u2010controlled, multi\u2010center, extension trial evaluating the efficacy of a new oral supplement in women with self\u2010perceived thinning hair","volume":"8","author":"Ablon G","year":"2015","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_7_15_1","unstructured":"IntelliStudio\u00ae Canfield Scientific Inc Parsippany NJ. 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