{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:49:00Z","timestamp":1759402140561},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T00:00:00Z","timestamp":1477353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dietary or supplementary intake of nutrients and other ingredients positively affects skin appearance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Evaluate a multicomponent nutritional supplement on photoaged skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>This multicenter, double\u2010blind, placebo\u2010controlled trial randomized healthy 35\u2010 to 65\u2010year\u2010old women with Fitzpatrick skin types I\u2013<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> and Glogau classification types <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> to a multicomponent nutritional supplement or placebo for 24 weeks. The primary endpoint was Investigator Global Assessment of overall facial appearance at week 24. Secondary endpoints included investigator\u2010 and subject\u2010rated assessments of the face, d\u00e9colletage, and hands; facial photography assessments (conducted by an independent panel of dermatologists); and instrumental measures. Analysis of variance was used to assess between\u2010group differences (<jats:italic>P<\/jats:italic> \u2264 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 194 randomized subjects, 171 completed the study. Subjects had a mean age of 53 years and were primarily white (81%), had Glogau <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (58%) and Fitzpatrick <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> (45%; significantly more supplement subjects had Fitzpatrick <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> [54%] <jats:italic>vs<\/jats:italic>. placebo [35%]; <jats:italic>P<\/jats:italic> = 0.039). At week 24, Investigator Global Assessment of overall facial appearance was numerically but not statistically better for supplement over placebo (mean difference: 0.14 [95% confidence interval: \u22120.16\u20130.44]; <jats:italic>P<\/jats:italic> = 0.358). A significant treatment\u2010by\u2010site interaction <jats:italic>(P =<\/jats:italic> 0.073) was observed; by\u2010site analyses revealed a significant difference at one of three geographical sites for supplement <jats:italic>vs<\/jats:italic>. placebo (<jats:italic>P<\/jats:italic> = 0.001). Differences on secondary endpoints were generally not significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the first multicenter study conducted with this multicomponent nutritional supplement, no significantly greater effects <jats:italic>vs<\/jats:italic>. placebo were observed on the primary endpoint, perhaps because of significant between\u2010site variability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12290","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T04:06:46Z","timestamp":1477454806000},"page":"120-131","source":"Crossref","is-referenced-by-count":10,"title":["A multicenter, placebo\u2010controlled, double\u2010blind clinical trial assessing the effects of a multicomponent nutritional supplement for treating photoaged skin in healthy women"],"prefix":"10.1111","volume":"16","author":[{"given":"Jay E","family":"Birnbaum","sequence":"first","affiliation":[{"name":"Jay E Birnbaum Consulting Montville NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H","family":"McDaniel","sequence":"additional","affiliation":[{"name":"Laser &amp; Cosmetic Center Virginia Beach VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Hickman","sequence":"additional","affiliation":[{"name":"Dermatology Consultants, Inc Lynchburg VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Dispensa","sequence":"additional","affiliation":[{"name":"Pfizer Consumer Healthcare Madison NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Le Moigne","sequence":"additional","affiliation":[{"name":"Pfizer Consumer Healthcare Madison NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry","family":"Buchner","sequence":"additional","affiliation":[{"name":"Canfield Scientific Fairfield NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711133372003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.5.666"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1090820X10378696"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03963.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12083"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-009-1001-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.24.012003.132320"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1998.tb00765.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5142\/jgr.2011.35.2.170"},{"key":"e_1_2_8_11_1","first-page":"1104","article-title":"Nutritional clinical studies in dermatology","volume":"12","author":"Liakou AI","year":"2013","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2012.01500.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12057"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2012.00631.x"},{"key":"e_1_2_8_15_1","first-page":"302","article-title":"Treating cutaneous photoaging in women with an oral supplement based on marine protein, concentrated acerola, grape seed extract and tomato extract, for 360 days","volume":"3","author":"Costa A","year":"2011","journal-title":"Surg Cosmet Dermatol"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962012000100006"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S98787"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602438"},{"key":"e_1_2_8_19_1","first-page":"25","article-title":"A randomized, double\u2010blind, placebo\u2010controlled clinical trial evaluating Imedeen\u00ae Derma One\u00ae for treating photodamaged skin","volume":"9","author":"Stephens TJ","year":"2016","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_8_20_1","first-page":"1453","article-title":"A review of clinical trials conducted with oral, multicomponent dietary supplements for improving photoaged skin","volume":"14","author":"Birnbaum J","year":"2015","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2005.00206.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323000503300301"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2009.00513.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.04.034"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12290","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12290","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T19:51:33Z","timestamp":1696276293000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,25]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/jocd.12290"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12290","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,25]]}}}