{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:17Z","timestamp":1787015597989,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,16]],"date-time":"2016-12-16T00:00:00Z","timestamp":1481846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Androgenetic alopecia (\n AGA<\/jats:styled-content>\n ) is the most common cause of alopecia in men. In the literature, although there are\n in\u00a0vitro<\/jats:italic>\n studies investigating the relationship between oxidative stress and\n AGA<\/jats:styled-content>\n , any\n in\u00a0vivo<\/jats:italic>\n study does not exist.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n Our aim was to evaluate the oxidative stress status in male patients with early\u2010onset\n AGA<\/jats:styled-content>\n by measuring total oxidant levels (\n TOS<\/jats:styled-content>\n ), total antioxidant levels (\n TAS<\/jats:styled-content>\n ), and oxidative stress index (\n OSI<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Our study included 33 male patients with early\u2010onset\n AGA<\/jats:styled-content>\n and 30 healthy men between ages of 18 and 30\u00a0years old.\n TAS<\/jats:styled-content>\n and\n TOS<\/jats:styled-content>\n measurements were taken, and\n OSI<\/jats:styled-content>\n was calculated.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n When\n TAS<\/jats:styled-content>\n ,\n TOS<\/jats:styled-content>\n , and\n OSI<\/jats:styled-content>\n levels were compared between patient and control groups, there was no difference for\n TAS<\/jats:styled-content>\n level, while\n TOS<\/jats:styled-content>\n and\n OSI<\/jats:styled-content>\n were significantly higher in patient group. In patient group, correlation between\n TAS<\/jats:styled-content>\n ,\n TOS<\/jats:styled-content>\n , and\n OSI<\/jats:styled-content>\n levels and age, and disease onset age and disease duration was evaluated. Highly significant negative correlation was determined between\n TAS<\/jats:styled-content>\n level and both age and disease duration. When\n TAS<\/jats:styled-content>\n ,\n TOS<\/jats:styled-content>\n , and\n OSI<\/jats:styled-content>\n levels were assessed according to\n AGA<\/jats:styled-content>\n stage, there was no significant difference between groups, while\n OSI<\/jats:styled-content>\n level was significantly higher in patients with family history.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n We found increased oxidative stress in younger patients with early\u2010onset\n AGA<\/jats:styled-content>\n . There is need for further molecular studies on the role of oxidative stress in the etiopathogenesis of\n AGA<\/jats:styled-content>\n . We also think that topical or systemic antioxidants can be promising in treatment of\n AGA<\/jats:styled-content>\n , especially for young patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.12300","type":"journal-article","created":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T12:08:37Z","timestamp":1481976517000},"page":"527-530","source":"Crossref","is-referenced-by-count":38,"title":["The role of oxidative stress in early\u2010onset androgenetic alopecia"],"prefix":"10.1111","volume":"16","author":[{"given":"Hilal","family":"Kaya Erdogan","sequence":"first","affiliation":[{"name":"Faculty of Medicine Department of Dermatology Eski\u015fehir Osmangazi University Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Is\u0131l","family":"Bulur","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Dermatology Eski\u015fehir Osmangazi University Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evin","family":"Kocaturk","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Eski\u015fehir Yunus Emre State Hospital Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahadir","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Dermatology Eski\u015fehir Osmangazi University Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep Nurhan","family":"Saracoglu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Dermatology Eski\u015fehir Osmangazi University Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozkan","family":"Alatas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Biochemistry Eski\u015fehir Osmangazi University Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(02)00093-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.116730"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2009.03.032"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.51923"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2005.08.008"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2003.11.015"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00659.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12286"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2014.10.008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701147"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.28"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.171566"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1684\/ejd.2010.1193","article-title":"The investigation of insulin resistance and metabolic syndrome in male patients with early\u2010onset androgenetic alopecia","volume":"21","author":"Mumcuo\u011flu C","year":"2011","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043798-200106000-00005"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.09.036"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/431425"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12300","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12300","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T20:29:33Z","timestamp":1696019373000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,16]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/jocd.12300"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12300","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,16]]}}}