{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:25:26Z","timestamp":1771007126177,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,29]],"date-time":"2017-01-29T00:00:00Z","timestamp":1485648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Meda Pharma"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>General skincare measures such as the use of moisturisers and products containing adequate photoprotection are important components of acne patients\u2019 management to complement the pharmacological regimen. Acne <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u20101,2 is a novel dermato\u2010cosmetic product which contains selective photofilters and active ingredients against the multifactorial pathophysiology of acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the tolerability of Acne <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u20101,2 and its effect on the clinical signs of acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This double\u2010blind, placebo\u2010controlled study randomized 40 adult patients with 10\u201025 comedones per half face to once\u2010daily application of Acne <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u20101,2 or placebo for 8\u00a0weeks. Evaluations after 4 and 8\u00a0weeks included the number of comedones, transepidermal water loss (<jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content>), sebum production, and tolerability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the Acne <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u20101,2 group, there was a significant 35% decrease in the mean number of comedones from 26 at baseline to 17 at Week 8 (<jats:italic>P<\/jats:italic>&lt;.001), a 7% significant reduction in <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> (9.32 to 8.66\u00a0g\/h\/m<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>&lt;.001), and a 24% significant reduction in sebum production (154.8 to 117.6\u00a0\u03bcg\/cm<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>&lt;.001). The reductions in <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> and sebum production were significantly greater than those in the placebo group at Weeks 4 and 8 (<jats:italic>P<\/jats:italic>&lt;0.05). There were no adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Acne <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u20101,2 was well tolerated and effective at reducing comedones and sebum production and improving epidermal barrier function. These results suggest that Acne <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u20101,2 is useful against acne\u2010prone facial skin, particularly as it targets sebum production, which topical pharmacological acne therapies do not address.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12309","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T04:54:26Z","timestamp":1485752066000},"page":"265-270","source":"Crossref","is-referenced-by-count":7,"title":["Acne <scp>RA<\/scp>\u20101,2, a novel <scp>UV<\/scp>\u2010selective face cream for patients with acne: Efficacy and tolerability results of a randomized, placebo\u2010controlled clinical study"],"prefix":"10.1111","volume":"16","author":[{"given":"Enza","family":"Cestone","sequence":"first","affiliation":[{"name":"Farcoderm s.r.l. 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