{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:10:13Z","timestamp":1779207013555,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T00:00:00Z","timestamp":1487721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Microdermabrasion and chemical peeling are popular, inexpensive, and safe methods for treatment of some skin disorders and to rejuvenate skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To study the alterations of the dermal connective tissue following salicylic acid peeling and microdermabrasion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty patients were participated in our study. All participants underwent facial salicylic acid 30% peel or microdermabrasion (10 cases in each group) weekly for 6\u00a0weeks. Punch biopsies were obtained from the clinically normal skin of the right postauricular region 1\u00a0week before treatment (control group). Other punch skin biopsies were obtained 1\u00a0week after the end of the treatments from the left postauricular area. This region was treated in a similar way to the adjacent lesional skin (treated group). We used routine histological techniques (H&amp;E stain), special stains (Masson trichrome and orcein stains), and image analyzer to study the alterations of the dermal connective tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our study demonstrates variations in the morphological changes between the control and the treated groups, and between chemical peels and microdermabrasion. Both salicylic acid 30% and microdermabrasion were associated with thickened epidermal layer, shallow dermal papillae, dense collagen, and elastic fibers. There was a significant increase among those treated sites vs control regarding epidermal thickness and collagen thickness. Also, there was a highly statistically significant increase among those treated with salicylic acid vs microdermabrasion regarding the epidermal, collagen, and elastin thickness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both methods stimulate the repair process. The mechanisms underlying these variations are open for further investigations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12315","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T04:22:50Z","timestamp":1487823770000},"source":"Crossref","is-referenced-by-count":25,"title":["Dermal morphological changes following salicylic acid peeling and microdermabrasion"],"prefix":"10.1111","volume":"16","author":[{"given":"Amira A","family":"Abdel\u2010Motaleb","sequence":"first","affiliation":[{"name":"Faculty of Medicine Department of Dermatology, Venereology and Andrology Assiut University  Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman E","family":"Abu\u2010Dief","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Histology Sohag University Sohag Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud RA","family":"Hussein","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Pathology Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/maj.2001.114445"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-822958"},{"key":"e_1_2_5_4_1","first-page":"32","article-title":"Evidence and considerations in the application of chemical peels in skin disorders and aesthetic resurfacing","volume":"3","author":"Rendon MI","year":"2010","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1584818"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2003.29384.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.104911"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1996.tb00344.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199804010-00037"},{"key":"e_1_2_5_10_1","first-page":"433","article-title":"Effect of topical tretinoin, chemical peeling and dermabrasion on p53 expression in facial skin","volume":"13","author":"El\u2010Domyati MM","year":"2003","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2008.07.004"},{"key":"e_1_2_5_12_1","first-page":"94","article-title":"Beneficial effects of pro\u2010\/antioxidant\u2010based nutraceuticals in the skin rejuvenation techniques","volume":"53","author":"Luca C","year":"2007","journal-title":"Cell Mol Biol"},{"issue":"2","key":"e_1_2_5_13_1","first-page":"18","article-title":"Alpha\u2010hydroxyacid chemical peeling agents: case studies and rationale for safe and effective use","volume":"73","author":"Briden ME","year":"2004","journal-title":"Cutis"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.11.1390"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200101000-00036"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2001.00291.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000113026.94292.0B"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170802524445"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630212345678"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12252"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.10.008"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.231"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1076-0512.2003.30107.x"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12315","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:29:57Z","timestamp":1696033797000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,22]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/jocd.12315"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12315","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,22]]}}}