{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:13:04Z","timestamp":1785795184687,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T00:00:00Z","timestamp":1490572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Over the counter cosmetics sold for local treatment of slight to moderate rosacea often state the claim of actively modulating rosacea pathogenesis. Factors involved in the pathogenesis of this common yet complex skin disorder include kallikrein\u2010related peptidase 5 (KLK<\/jats:styled-content>5), LL<\/jats:styled-content>\u201037, as well as protease\u2010activated receptor 2 (PAR<\/jats:styled-content>2) and vascular endothelial growth factor (VEGF<\/jats:styled-content>).<\/jats:p><\/jats:sec>Objective<\/jats:title>The objective was to prove the modulating effect of the cosmetic skin care agent Dermasence Refining Gel (DRG<\/jats:styled-content>) on factors involved in rosacea pathogenesis.<\/jats:p><\/jats:sec>Methods<\/jats:title>We analyzed the effect of DRG<\/jats:styled-content> on the expression of KLK<\/jats:styled-content>5, LL<\/jats:styled-content>\u201037, PAR<\/jats:styled-content>2, and VEGF<\/jats:styled-content> in an in vitro skin model of human reconstituted epidermis.<\/jats:p><\/jats:sec>Results<\/jats:title>The expression of CAMP<\/jats:styled-content><\/jats:italic> (LL<\/jats:styled-content>\u201037 gene, fold change \u22124.19 [\u00b10.11]), VEGFA<\/jats:styled-content><\/jats:italic> (fold change \u22122.55 [\u00b10.12]) and PAR<\/jats:styled-content>2<\/jats:italic> (\u22121.33 [\u00b10.12]) was reduced, KLK<\/jats:styled-content>5<\/jats:italic> expression increased (fold change 2.06 (\u00b10.08)) after 18 h of treatment with DRG<\/jats:styled-content> in comparison to treatment with the matrix gel only. The reduction in CAMP<\/jats:styled-content><\/jats:italic> expression was significant (P<\/jats:italic><.01). The protein expression of all four inflammatory markers was markedly reduced after 18 hours of DRG<\/jats:styled-content> treatment in comparison to baseline (0 hour), by measure of fluorescence intensity.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We show evidence explaining the anti\u2010inflammatory effect of Dermasence Refining Gel in rosacea pathogenesis in vitro. The adjunctive use of DRG<\/jats:styled-content> in mild to moderate rosacea as a topical cosmetic seems medically reasonable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12323","type":"journal-article","created":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T04:12:43Z","timestamp":1490674363000},"source":"Crossref","is-referenced-by-count":5,"title":["Dermasence refining gel modulates pathogenetic factors of rosacea in vitro"],"prefix":"10.1111","volume":"16","author":[{"given":"C","family":"Borelli","sequence":"first","affiliation":[{"name":"Unit of Esthetic and Laser Department of Dermatology Eberhard\u2010Karls\u2010Universiy of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Becker","sequence":"additional","affiliation":[{"name":"MolCare Consulting Wiesent Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Thude","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Fehrenbacher","sequence":"additional","affiliation":[{"name":"Unit of Esthetic and Laser Department of Dermatology Eberhard\u2010Karls\u2010Universiy of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Isermann","sequence":"additional","affiliation":[{"name":"P&M Cosmetics GmbH & Co. KG M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.04.007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.05.019"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1616"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.07.014"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2011.6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.7.1069"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03340.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2014.55.6.1648"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2011.5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-011-2145-6"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02850197"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2014.06.006"},{"key":"e_1_2_6_14_1","first-page":"1351","article-title":"Comparative anti\u2010inflammatory effects of anti\u2010arthritic herbal medicines and ibuprofen","volume":"9","author":"Kang JJ","year":"2014","journal-title":"Nat Prod Commun"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_6_16_1","first-page":"20","article-title":"Kallikrein 5\u2010mediated inflammation in rosacea: clinically relevant correlations with acute and chronic manifestations in rosacea and how individual treatments may provide therapeutic benefit","volume":"7","author":"Two AM","year":"2014","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.04.045"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.351"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12030"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.14"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:29:41Z","timestamp":1696033781000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,27]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/jocd.12323"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12323","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,27]]}}}