{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T17:53:26Z","timestamp":1775584406831,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T00:00:00Z","timestamp":1490832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Strategic Research Foundation Grant-aided Project for Private Universities","award":["S1311011"],"award-info":[{"award-number":["S1311011"]}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Pruritus frequently reduces quality of life (<jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>) in patients with senile xerosis. This study investigated the moisturizing and antipruritic effects of a topical emollient containing a diethylene glycol\/dilinoleic acid copolymer (D\/<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>) in patients with pruritic senile xerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010blind study involved 50 subjects, aged 50\u201075 years. Patients were randomized to self\u2010applied treatment of the lower legs with 10% (n = 20) or 20% (n = 20) D\/<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>\u2010containing cream, white petrolatum (n = 5), or no treatment (n = 5) thrice daily for four weeks. Clinical scores of skin dryness and scratch marks, skin conductance, and Skindex\u201016 were evaluated before and after treatment. The degree of pruritus was evaluated by visual analog scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>) score once a week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients treated with 10% and 20% D\/<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> showed significant improvements in skin dryness and scratch mark scores, as well as increased skin conductance, compared with the untreated group, whereas white petrolatum treatment improved only skin dryness scores. Moreover, patients treated with 20% D\/<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> showed significant improvements in skin dryness scores and skin conductance compared with white petrolatum treatment. The <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> scores in the D\/<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>\u2010treated and white petrolatum\u2010treated groups were significantly lower than in the untreated group, being particularly lower after one week of treatment with 20% D\/<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Topical application of an emollient containing D\/<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> is effective in improving skin dryness and pruritus in patients with senile xerosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12332","type":"journal-article","created":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T05:26:48Z","timestamp":1490851608000},"source":"Crossref","is-referenced-by-count":17,"title":["Efficacy of an emollient containing diethylene glycol\/dilinoleic acid copolymer for the treatment of dry skin and pruritus in patients with senile xerosis"],"prefix":"10.1111","volume":"16","author":[{"given":"Runa","family":"Izumi","sequence":"first","affiliation":[{"name":"Fancl Research Institute Fancl Corporation Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Negi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Juntendo University Urayasu Hospital Urayasu Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamie","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Fancl Research Institute Fancl Corporation Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsutoshi","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Institute for Environmental and Gender Specific Medicine Juntendo University Graduate School of Medicine Urayasu Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Kamo","sequence":"additional","affiliation":[{"name":"Institute for Environmental and Gender Specific Medicine Juntendo University Graduate School of Medicine Urayasu Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Suga","sequence":"additional","affiliation":[{"name":"Department of Dermatology Juntendo University Urayasu Hospital Urayasu Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoko","family":"Matsukuma","sequence":"additional","affiliation":[{"name":"Fancl Research Institute Fancl Corporation Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Takamori","sequence":"additional","affiliation":[{"name":"Department of Dermatology Juntendo University Urayasu Hospital Urayasu Chiba Japan"},{"name":"Institute for Environmental and Gender Specific Medicine Juntendo University Graduate School of Medicine Urayasu Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.282023"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1998.tb02371.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12470233"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1989.tb08190.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1201\/b16573-18"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.178"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2010.07.005"},{"key":"e_1_2_5_9_1","first-page":"321","article-title":"Efficacy of topical hydrating and emollient lotion containing 10% urea ISDIN\u00ae plus dexpanthenol (Ureadin Rx 10) in the treatment of skin xerosis and pruritus in hemodialysis patients: An open prospective pilot trial","volume":"146","author":"Castello M","year":"2011","journal-title":"G Ital Dermatol venereol"},{"key":"e_1_2_5_10_1","first-page":"29","article-title":"Treatment of xerosis with a topical formulation containing glyceryl glucoside, natural moisturizing factors, and ceramide","volume":"5","author":"Weber TM","year":"2012","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_5_11_1","first-page":"193","article-title":"Development of the novel plant\u2010derived lanolin substitute and its cosmetic applications","volume":"57","author":"Ohashi Y","year":"2006","journal-title":"J Cosmetic Sci"},{"key":"e_1_2_5_12_1","unstructured":"SuzukiT TorimaruW IzumiR et al.A Novel Oligomer Ester with Anti\u2010Irritant Effects on Barrier\u2010Damaged Skin[poster]. 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