{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:29:16Z","timestamp":1790432956511,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T00:00:00Z","timestamp":1499126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Merz Pharmaceuticals GmbH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Jawline reshaping by replacing volume has become an indispensable component of modern facial rejuvenation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate calcium hydroxylapatite (CaHA) for the treatment of an aging jawline in a routine setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five investigators enrolled 35 subjects requesting jawline rejuvenation with Ca<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>. Injections were performed according to investigators usual practice. Baseline and post\u2010treatment scores were evaluated using Merz Aesthetics Scales\u00ae. Follow\u2010up visits took place at Day 30 (Day 60 for those with touch\u2010up at Day 30), 180, and 360. Physician and patient satisfaction, esthetic impact of treatment, and adverse events were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Improvements in jawline contour compared with baseline were statistically significant at each visit, with scores of 2.42 (moderate to severe sagging) at baseline, 1.02 (mild) at Day 30\/60 (<jats:italic>P<\/jats:italic>\u2264.0001), 1.11 at Day 180 (<jats:italic>P<\/jats:italic>\u2264.0001), and 1.45 at Day 360 (<jats:italic>P<\/jats:italic>=.0015). Statistically significant improvements in marionette line scores were also observed. Investigators rated results as \u201cimproved\u201d to \u201cvery much improved\u201d in all subjects up to Day 180, and in 81% of subjects at Day 360. Satisfaction with treatment was very high. Adverse events were mostly mild and related to either the procedure or injection technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ca<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> is a very effective agent for restoring jawline contour in routine practice and is associated with high levels of physician and patient satisfaction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12335","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T14:11:31Z","timestamp":1499177491000},"page":"342-347","source":"Crossref","is-referenced-by-count":24,"title":["Restoring jawline contour with calcium hydroxylapatite: A\u00a0prospective, observational study"],"prefix":"10.1111","volume":"16","author":[{"given":"Martine","family":"Baspeyras","sequence":"first","affiliation":[{"name":"Centre Bordelais Dermatologie Esthetique Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Marie","family":"Dallara","sequence":"additional","affiliation":[{"name":"Centre Laser Dermatologique Laser MD Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Cartier","sequence":"additional","affiliation":[{"name":"Square Saint Jean Arras France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010H\u00e9l\u00e8ne","family":"Charavel","sequence":"additional","affiliation":[{"name":"Rue Saint Florentin Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Dumas","sequence":"additional","affiliation":[{"name":"Avenue Carnot Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02247.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(09)72531-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000265403.66886.54"},{"key":"e_1_2_7_5_1","unstructured":"Merz Aesthetics.\u2018FACE VALUE\u2019 beauty survey \u2212 2012 Report."},{"key":"e_1_2_7_6_1","unstructured":"American Society for Aesthetic Plastic Surgery (ASAPS).Cosmetic surgery national data bank statistics 2015.http:\/\/www.surgery.org\/sites\/default\/files\/Stats2015.pdf. 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