{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T19:28:27Z","timestamp":1776713307355,"version":"3.51.2"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T00:00:00Z","timestamp":1490400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Bioenx s.r.l"},{"name":"Biodue S.p.A"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperandrogenism and reduced skin autophagy have been implicated in the pathogenesis of adult female acne (<jats:styled-content style=\"fixed-case\">AFA<\/jats:styled-content>). Here, we tested whether a ready\u2010to\u2010use peel\u2010off facial mask containing myoinositol (an androgen inhibitor) and trehalose\u2010loaded liposomes (as activators of cutaneous autophagy) applied overnight every other day for 60 days can improve <jats:styled-content style=\"fixed-case\">AFA<\/jats:styled-content>. We also sought to investigate the molecular mechanisms underlying the clinical effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We conducted an uncontrolled, open\u2010label clinical study in 40 cases of <jats:styled-content style=\"fixed-case\">AFA<\/jats:styled-content> to investigate the effect of the facial mask on lesion count, sebum production (measured with the Sebutape\u00ae technique), and Global Acne Grading System (<jats:styled-content style=\"fixed-case\">GAGS<\/jats:styled-content>) scale. We also investigated the changes from baseline to the end of treatment in androgen and beclin\u20101 levels (as a marker of authophagy) in skin biopsy supernatants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty Caucasian patients with <jats:styled-content style=\"fixed-case\">AFA<\/jats:styled-content> were enrolled. Changes in clinical and molecular endpoints before and after treatment were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean counts of comedones, papules, pustules, and nodular lesions decreased significantly (all <jats:italic>P<\/jats:italic>&lt;.001). The mean Sebutape\u00ae score was reduced from 3.4\u00b10.6 to 1.8\u00b10.2 (<jats:italic>P<\/jats:italic>&lt;.001), whereas the mean <jats:styled-content style=\"fixed-case\">GAGS<\/jats:styled-content> scale score decreased from 16.8\u00b15.3 at baseline to 9.8\u00b14.6 after treatment (<jats:italic>P<\/jats:italic>&lt;.001). A significant decrease in testosterone and dehydroepiandrosterone sulfate in skin biopsy supernatants was observed, whereas beclin\u20101 levels increased significantly (<jats:italic>P<\/jats:italic>&lt;.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A ready\u2010to\u2010use peel\u2010off facial mask containing myoinositol and trehalose\u2010loaded liposomes improved the cosmetic appearance of <jats:styled-content style=\"fixed-case\">AFA<\/jats:styled-content> by reducing cutaneous androgen content and promoting skin autophagy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12340","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T10:07:44Z","timestamp":1490436464000},"page":"480-484","source":"Crossref","is-referenced-by-count":10,"title":["A peel\u2010off facial mask comprising myoinositol and trehalose\u2010loaded liposomes improves adult female acne by reducing local hyperandrogenism and activating autophagy"],"prefix":"10.1111","volume":"16","author":[{"given":"Gabriella","family":"Fabbrocini","sequence":"first","affiliation":[{"name":"Section of Dermatology Department of Clinical Medicine and Surgery University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Capasso","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Clinical Medicine and Surgery University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Donnarumma","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Clinical Medicine and Surgery University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariateresa","family":"Cantelli","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Clinical Medicine and Surgery University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Le Ma\u00eetre","sequence":"additional","affiliation":[{"name":"Private Dermatology Practice Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Monfrecola","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Clinical Medicine and Surgery University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3908-0290","authenticated-orcid":false,"given":"Enzo","family":"Emanuele","sequence":"additional","affiliation":[{"name":"2E Science Robbio (PV) 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