{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:20:10Z","timestamp":1784035210221,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T00:00:00Z","timestamp":1492473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Photoaging is a severe skin damage that occurs as a result of exposure to external elements, primarily ultraviolet (<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>) irradiation. Chronically, <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010irradiated skin exhibits the signs of sunburn and hyperpigmentation with the destruction of connective tissues. Previously, <jats:italic>Boesenbergia pandurata<\/jats:italic> (<jats:italic>B.\u00a0pandurata<\/jats:italic>) and its active compound panduratin A showed antiphotoaging activities in\u00a0vitro and in\u00a0vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to investigate the clinical efficacy of <jats:italic>B.\u00a0pandurata<\/jats:italic> intake on skin hydration, gloss, wrinkling, and elasticity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A double\u2010blind, placebo\u2010controlled trial was conducted to clinically evaluate the effect of <jats:italic>B.\u00a0pandurata<\/jats:italic> ethanol extract (<jats:styled-content style=\"fixed-case\">BPE<\/jats:styled-content>) containing 8% of panduratin A on human skin hydration, gloss, wrinkling, and elasticity. Ninety\u2010two subjects were randomly assigned to receive tablets containing either <jats:styled-content style=\"fixed-case\">BPE<\/jats:styled-content> or placebo for 12 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The test group had significantly increased skin hydration and gloss and decreased wrinkling compared to the placebo group at 12\u00a0weeks. There was no significant difference in skin elasticity between the two groups; however, the increment rate in the test group was higher than that in the placebo group at 12\u00a0weeks. None of the subjects developed adverse symptoms during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that <jats:styled-content style=\"fixed-case\">BPE<\/jats:styled-content> can be used as a nutraceutical or nutricosmetic material for improving human skin hydration, gloss, and wrinkling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12343","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T03:57:06Z","timestamp":1492574226000},"page":"512-519","source":"Crossref","is-referenced-by-count":27,"title":["Oral intake of <i>Boesenbergia pandurata<\/i> extract improves skin hydration, gloss, and wrinkling: A randomized, double\u2010blind, and placebo\u2010controlled study"],"prefix":"10.1111","volume":"16","author":[{"given":"Do Un","family":"Kim","sequence":"first","affiliation":[{"name":"Newtree Co., Ltd. Sungnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Chul","family":"Chung","sequence":"additional","affiliation":[{"name":"Newtree Co., Ltd. Sungnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Yonsei University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5550-6661","authenticated-orcid":false,"given":"Jae\u2010Kwan","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Yonsei University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,18]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"s12","article-title":"The role of elastin and collagen in cutaneous aging: intrinsic aging versus photoexposure","volume":"7","author":"Uitto J","year":"2008","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2010.00574.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08108.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.11.1462"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(00)00098-X"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0781.2000.160601.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2011.04.011"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014830"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(01)00451-4"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.60086"},{"key":"e_1_2_5_12_1","first-page":"224","article-title":"Antimicrobial effects of Boesenbergia pandurata and Piper sarmentosum leaf extracts on planktonic cells and biofilm of oral pathogens","volume":"23","author":"Taweechaisupapong S","year":"2010","journal-title":"Pak J Pharm Sci"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms13010994"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/473637"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-012-9513-y"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2011.01379.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-864149"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.51.87"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3163"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1081352"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1034297"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2007.1041"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10068-012-0233-8"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2010.00608.x"},{"key":"e_1_2_5_25_1","volume-title":"Guideline for Efficacy Evaluation of Functional Cosmetics","author":"Korea Food and Drug Administration","year":"2005"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.proche.2014.12.003"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2008.09.002"},{"key":"e_1_2_5_28_1","first-page":"19","article-title":"Safety evaluation of ethanol extracts from Boesenbergia rotunda (L.) 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