{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:34:26Z","timestamp":1793900066747,"version":"4.8.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,4,22]],"date-time":"2017-04-22T00:00:00Z","timestamp":1492819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n There is no gold standard treatment for facial acne scars, and overall, little literature exists about the combination therapy for treatment of acne scar.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n \n The aim of this study was to evaluate the efficacy of fractionated microneedle radiofrequency (\n FMR<\/jats:styled-content>\n ) vs\n FMR<\/jats:styled-content>\n combined with subcision for the treatment of atrophic acne scars.\n <\/jats:p>\n <\/jats:sec>\n \n Patients\/Methods<\/jats:title>\n \n This was a randomized, split\u2010face clinical study of 25 patients with II\u2010IV Fitzpatrick skin types with moderate to severe facial atrophic acne scars. Initially, standard subcision by Nokor needle was performed on one side. Two weeks after subcision,\n FMR<\/jats:styled-content>\n treatment was performed on both cheeks of each participant. Second and third\n FMR<\/jats:styled-content>\n treatment sessions were performed within 4\u2010week intervals. Two\u2010blinded dermatologists performed clinical assessments using a quartile grading scale, and patients were also asked to judge their satisfaction using a visual analog scale (\n VAS<\/jats:styled-content>\n ) scoring system.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The age of the patients varied from 24 to 40 years (mean: 30.08\u00b14.94 years). Only nine patients (36%) were males. Clinical assessment by two\u2010blinded dermatologists showed statistically significant improvement in the combination (\n FMR<\/jats:styled-content>\n +subcision) group (\n P<\/jats:italic>\n =.009). Patient satisfaction was statistically significantly better in the combination group (\n P<\/jats:italic>\n =.001). A darkening of skin phototype was associated with a decrease in patient's satisfaction\n VAS<\/jats:styled-content>\n score (\n P<\/jats:italic>\n =.07).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The combination of subcision and\n FMR<\/jats:styled-content>\n is a safe and effective modality for mixed type acne scars. Additional randomized clinical study with long\u2010term follow\u2010up is necessary for further evaluation of\n FMR<\/jats:styled-content>\n in combination with other procedures.\n <\/jats:p>\n \n The full trial protocol can be accessed in:\n http:\/\/www.irct.ir\/searchresult.php?keyword=%20%20IRCT2016103130597N1&id=30597&number=1&field=a&prt=1&total=1&m=1<\/jats:ext-link>\n .\n <\/jats:p>\n \n The clinical trial registration number is\n IRCT<\/jats:styled-content>\n 2016103130597N1.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.12346","type":"journal-article","created":{"date-parts":[[2017,4,22]],"date-time":"2017-04-22T01:27:48Z","timestamp":1492824468000},"page":"223-229","source":"Crossref","is-referenced-by-count":44,"title":["Efficacy of fractionated microneedle radiofrequency with and without adding subcision for the treatment of atrophic facial acne scars: A randomized split\u2010face clinical study"],"prefix":"10.1111","volume":"16","author":[{"given":"Gita","family":"Faghihi","sequence":"first","affiliation":[{"name":"Department of Dermatology Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-6186","authenticated-orcid":false,"given":"Nazila","family":"Poostiyan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Asilian","sequence":"additional","affiliation":[{"name":"Department of Dermatology Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences Isfahan 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