{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T19:07:47Z","timestamp":1744225667831,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T00:00:00Z","timestamp":1494288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008040","name":"Kao Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Many people use lip care products daily to prevent dry lips. However, some people, especially those with sensitive skin\u2010consciousness, complain of various skin problems on their lips including contact dermatitis caused by lip care products. Dry lips have decreased water holding capacity and cutaneous barrier function as well as reduced stratum corneum ceramide levels. In this study, we investigated the usefulness of a newly formulated lip balm containing pseudo\u2010ceramide for the dry lips of subjects with sensitive skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Thirty subjects with dry lips and sensitive skin\u2010consciousness used the test lip balm more than twice a day for 4 weeks. Lip conditions were evaluated before and after 2 and 4 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Visual evaluation by a dermatologist showed that overall improvements were observed in all subjects as early as week 2. After 4 weeks of usage, 27% of the subjects were objectively judged as \u201cmarkedly improved\u201d and 60% of the subjects were judged as \u201cimproved\u201d. No adverse event developed throughout the test period, and all subjects were able to use the lip balm safely for 4 weeks. Usefulness was judged based on all evaluation items, and 27%, 70%, and 3% of the subjects were judged as \u201cvery useful,\u201d \u201cuseful,\u201d and \u201cslightly useful,\u201d respectively. Ninety percentage of the subjects expressed improvement and acceptance of the lip balm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on these results, the newly formulated lip balm containing pseudo\u2010ceramide is very useful for the lip care of sensitive skin\u2010conscious subjects as well as for daily use by healthy subjects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12351","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T04:23:02Z","timestamp":1494390182000},"page":"84-89","source":"Crossref","is-referenced-by-count":7,"title":["The efficacy of a lip balm containing pseudo\u2010ceramide on the dry lips of sensitive skin\u2010conscious subjects"],"prefix":"10.1111","volume":"17","author":[{"given":"Keiichi","family":"Isoda","sequence":"first","affiliation":[{"name":"Department of Dermatology Mie University Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"R&amp;D Development Research Kao Corporation Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensuke","family":"Yoshida","sequence":"additional","affiliation":[{"name":"R&amp;D Development Research Kao Corporation Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiko","family":"Tamura","sequence":"additional","affiliation":[{"name":"R&amp;D Development Research Kao Corporation Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nami","family":"Atsuta","sequence":"additional","affiliation":[{"name":"R&amp;D Development Research Kao Corporation Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Ishida","sequence":"additional","affiliation":[{"name":"R&amp;D Development Research Kao Corporation Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2699-8932","authenticated-orcid":false,"given":"Yutaka","family":"Takagi","sequence":"additional","affiliation":[{"name":"R&amp;D Development Research Kao Corporation Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Mizutani","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mie University Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,9]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"10","article-title":"Lip skin care and cosmetics","volume":"108","author":"Hikima R","year":"2005","journal-title":"MB Derma"},{"key":"e_1_2_7_3_1","first-page":"64","article-title":"Study of lip surface \u2010 characteristics of chapped lip","volume":"13","author":"Arai S","year":"1989","journal-title":"J Jap Cosmet Sci Soc"},{"key":"e_1_2_7_4_1","first-page":"14","article-title":"Recent trends of research and development of lipsticks. 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