{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:27:21Z","timestamp":1780086441341,"version":"3.54.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,14]],"date-time":"2017-05-14T00:00:00Z","timestamp":1494720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004357","name":"Procter and Gamble","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine whether the oxidative stress transmitted to newly grown hair from an unhealthy scalp has physical consequences to the cuticular condition and function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A uniquely designed 24\u2010week clinical study included 8 weeks of pretreatment with a cosmetic shampoo and 16 weeks of treatment with either a potentiated zinc pyrithione (<jats:styled-content style=\"fixed-case\">ZPT<\/jats:styled-content>) antidandruff shampoo or a placebo cosmetic shampoo. This clinical design allowed the growth and acquisition of hair samples under conditions of varying but known scalp health as a result of treating a dandruff\/seborrheic dermatitis (D\/<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) population. Two complementary methods were used to characterize the integrity of the cuticular surface. Hair surface hydrophobicity was assessed by quantifying water wetting force using a Wilhelmy balance method. Surface structure and porosity were assessed using dynamic vapor sorption (<jats:styled-content style=\"fixed-case\">DVS<\/jats:styled-content>) to gravimetrically quantify water sorption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Chemical oxidative stress to pre\u2010emergent hair has been shown to have negative consequences to hair surface structure. Compared to a placebo shampoo control, use of a potentiated <jats:styled-content style=\"fixed-case\">ZPT<\/jats:styled-content> shampoo improved scalp health and significantly improved the following attributes associated with healthy hair: hair surface hydrophobicity (surface energy) and cuticular moisture barrier effectiveness (dynamic vapor sorption).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pre\u2010emergent hair can be negatively impacted by the oxidative stress that occurs with an unhealthy scalp, possibly due to metabolic activity of resident microbes. Manifestations of the oxidative stress include altered cuticle surface properties that are responsible for its protective function; these effects are similar in type to those observed by bleaching post\u2010emergent hair. These alterations have the potential to make the hair, once emerged from the scalp, more susceptible to the cumulative physical and chemical insults responsible for hair feel and look, fiber integrity, and overall retention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12355","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T04:36:42Z","timestamp":1494823002000},"page":"105-111","source":"Crossref","is-referenced-by-count":16,"title":["Incubatory environment of the scalp impacts pre\u2010emergent hair to affect post\u2010emergent hair cuticle integrity"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7694-2780","authenticated-orcid":false,"given":"James R.","family":"Schwartz","sequence":"first","affiliation":[{"name":"The Procter &amp; Gamble Company Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Henry","sequence":"additional","affiliation":[{"name":"The Procter &amp; Gamble Company Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy M.","family":"Kerr","sequence":"additional","affiliation":[{"name":"The Procter &amp; Gamble Company Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Flagler","sequence":"additional","affiliation":[{"name":"The Procter &amp; Gamble Company Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve H.","family":"Page","sequence":"additional","affiliation":[{"name":"The Procter &amp; Gamble Company Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Redman\u2010Furey","sequence":"additional","affiliation":[{"name":"The Procter &amp; Gamble Company Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.276"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1088\/1742-6596\/100\/5\/052034","article-title":"A closer look at the complex hydrophilic\/hydrophobic interactions forces at the human hair surface","volume":"100","author":"Baghdadli N","year":"2008","journal-title":"J Phys Conf Ser"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2004.10.003"},{"key":"e_1_2_7_5_1","first-page":"410","article-title":"ToF\u2010SIMS characterization of the lipid layer on the hair surface. 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