{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:29Z","timestamp":1787015549073,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T00:00:00Z","timestamp":1500422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitiligo is a pigmentary disorder of skin affecting at least 1% of the world population of all races in both sexes. Its importance is mainly due to subsequent social and psychological problems rather than clinical complications. Various treatment choices are available for vitiligo; however, laser\u2010based courses have shown to give more acceptable results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The aim of this trial was to evaluate the efficacy of Er:\n                      <jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content>\n                      laser as a supplementary medicine to topical 5\n                      <jats:styled-content style=\"fixed-case\">FU<\/jats:styled-content>\n                      and clobetasol in vitiligo patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Two comparable vitiligo patches from 38 eligible patients were randomized to receive topical 5\n                      <jats:styled-content style=\"fixed-case\">FU<\/jats:styled-content>\n                      and clobetasol in control group and additional Er:\n                      <jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content>\n                      laser in intervention group. Major outcomes of interest were the size of patch and pigmentation score at randomization and 2 and 4\u00a0months after therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Final sample included 18 (47%) male patients and age of 35.66\u00b18.04. The performance Er:\n                      <jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content>\n                      group was superior in all sites. Reduction in the size of patches was greater in Er:\n                      <jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content>\n                      group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value=.004). Also, this group showed a higher pigmentation scores in the trial period than control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value&lt;.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Greater reduction in the size and increase in pigmentation score was seen in Er:\n                      <jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content>\n                      group especially for short periods after therapy and repeating laser sessions may help improving final outcomes. Er:\n                      <jats:styled-content style=\"fixed-case\">AYG<\/jats:styled-content>\n                      could help in reducing complications of long\u2010term topical treatments, achieving faster response, and improving patient adherence.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.12373","type":"journal-article","created":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T07:54:53Z","timestamp":1500450893000},"page":"165-170","source":"Crossref","is-referenced-by-count":16,"title":["Potential emerging treatment in vitiligo using Er:\n                    <scp>YAG<\/scp>\n                    in combination with 5\n                    <scp>FU<\/scp>\n                    and clobetasol"],"prefix":"10.1111","volume":"17","author":[{"given":"Fatemeh","family":"Mokhtari","sequence":"first","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center Department of Dermatology School of Medicine Isfahan University of Medical 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Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba","family":"Iraji","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center Department of Dermatology School of Medicine Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gita","family":"Faghihi","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center Department of Dermatology School of Medicine Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayed Mohsen","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Health Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behzad","family":"Bafandeh","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center Department of Dermatology School of Medicine Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20090603"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.02.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2000.01749.x"},{"key":"e_1_2_8_5_1","first-page":"S17","article-title":"Comparing the efficacy of topical clobetasol 0.05% plus 5FU 5% cream vs. topical clobetasol 0.05% alone in the treatment of vitiligo","volume":"17","author":"Shahmoradi Z","year":"2012","journal-title":"J Res Med 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