{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:59:29Z","timestamp":1790038769932,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T00:00:00Z","timestamp":1505952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002799","name":"Capital Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002799","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cutaneous features of hyperandrogenism in polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>) include acne, hirsutism, seborrhea, androgenic alopecia (AGA), and acanthosis nigricans (AN). However, the relationships have not been well known broadly in terms of clinical hyperandrogenism and biochemical markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to investigate biochemical and metabolic parameters in relation to cutaneous characters women in with and without <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>. <jats:bold>Methods:<\/jats:bold> This was a cross\u2010sectional retrospective study including 186 women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and 113 age\u2010matched without <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> women. Acne grade, hirsutism, seborrhea, AGA, and AN were recorded. Hormonal and metabolic parameters were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most common finding was acne, and <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> was the least dermatological manifestations between <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> groups. The severity location and type of acne did not differ in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> women compared to non\u2010<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> women. Significant differences were found with respect to free androgen index (FAI) (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.036), sex hormone\u2010binding globulin (SHBG) (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.023), and body mass index (BMI) (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.001) between <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> with acne and <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> without acne groups. Overall, age (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.005) was significantly decreased, while <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.004) was significantly higher in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> with hirsutism. The mean serum total testosterone (TT), dehydroepiandrosterone sulfate, and <jats:styled-content style=\"fixed-case\">FAI<\/jats:styled-content> were significantly elevated, but <jats:styled-content style=\"fixed-case\">SHBG<\/jats:styled-content> was decreased between <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> with and without hirsutism groups. There were significantly different <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.018) and triglyceride (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.024) except other hormonal parameter of without <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study indicated a strong correlation between hirsutism and metabolic abnormalities. Hirsutism is the most common cutaneous finding in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> women. Acne and <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> are associated with other manifestations of clinical hyperandrogenism, but not obvious markers of biochemical hyperandrogenemia and metabolic dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12387","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T13:33:04Z","timestamp":1506000784000},"page":"511-517","source":"Crossref","is-referenced-by-count":27,"title":["Prevalence of dermatologic manifestations and metabolic biomarkers in women with polycystic ovary syndrome in north China"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0372-1386","authenticated-orcid":false,"given":"Jin\u2010ge","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Dermatology Fu Xing Hospital of Capital Medical University Beijing 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