{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:34:57Z","timestamp":1787697297072,"version":"build-2784847793"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T00:00:00Z","timestamp":1502150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Brittle nail syndrome is a common problem among women and refers to nails that exhibit surface roughness, raggedness, and peeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The goal of this study was to investigate whether daily oral supplementation with collagen peptides alleviates the symptoms of brittle nails and improves nail growth rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this open\u2010label, single\u2010center trial, 25 participants took 2.5\u00a0g of specific bioactive collagen peptides (<jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> VERISOL<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup>) once daily for 24\u00a0weeks followed by a 4\u2010week off\u2010therapy period. Nail growth rate and the frequency of cracked and\/or chipped nails as well as an evaluation of symptoms and global clinical improvement score of brittle nails were assessed by a physician during treatment and 4\u00a0weeks after discontinuation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bioactive collagen peptides treatment promoted an increase of 12% nail growth rate and a decrease of 42% in the frequency of broken nails. Additionally, 64% of participants achieved a global clinical improvement in brittle nails, and 88% of participants experienced an improvement 4\u00a0weeks post\u2010treatment. The majority of participants (80%) agreed that the use of <jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content> improved their nails' appearance, and were completely satisfied with the performance of the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrated that the daily ingestion of <jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content> increased nail growth and improved brittle nails in conjunction with a notable decrease in the frequency of broken nails.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12393","type":"journal-article","created":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T11:02:37Z","timestamp":1502190157000},"page":"520-526","source":"Crossref","is-referenced-by-count":39,"title":["Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0615-9026","authenticated-orcid":false,"given":"Doris","family":"Hexsel","sequence":"first","affiliation":[{"name":"Brazilian Center for Studies in Dermatology Porto Algre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Zague","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology Institute of Biomedical Sciences University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schunck","sequence":"additional","affiliation":[{"name":"Collagen Research Institute (CRI) Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Siega","sequence":"additional","affiliation":[{"name":"Brazilian Center for Studies in Dermatology Porto Algre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda O","family":"Camozzato","sequence":"additional","affiliation":[{"name":"Brazilian Center for Studies in Dermatology Porto Algre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Oesser","sequence":"additional","affiliation":[{"name":"Collagen Research Institute (CRI) Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2130.2004.00084.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2012.01518.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2010.03.037"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2014.12.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2007.00290.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-008-0888-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.10.1891"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf9031487"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf050206p"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2010.0085"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.00827.x"},{"key":"e_1_2_6_13_1","first-page":"1","article-title":"An oral supplementation based on hydrolyzed collagen and vitamins improves skin elasticity and dermis echogenicity: a clinical placebo\u2010controlled study","volume":"4","author":"Maia\u2010Campos P","year":"2015","journal-title":"Clin Pharmacol Biopharm"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2010.01782.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355523"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351376"},{"key":"e_1_2_6_17_1","first-page":"96","article-title":"Efficacy and safety study of tazarotene cream 0.1% for the treatment of brittle nail syndrome","volume":"87","author":"Sherber NS","year":"2011","journal-title":"Cutis"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.09.002"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.02.091"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000369830"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2006.00232.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.7606"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.12.006"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12051"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12393","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:29:45Z","timestamp":1696033785000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,8]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/jocd.12393"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12393","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,8]]}}}