{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:33:53Z","timestamp":1793072033856,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,8,20]],"date-time":"2017-08-20T00:00:00Z","timestamp":1503187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,8,20]],"date-time":"2017-08-20T00:00:00Z","timestamp":1503187200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n Multiple treatment options are introduced in treatment of vitiligo but the response is unsatisfactory.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n In this prospective, randomized, comparative trial, we studied the effect of combined treatment with fractional carbon dioxide (\n CO<\/jats:styled-content>\n 2<\/jats:sub>\n ) laser, platelet\u2010rich plasma (\n PRP<\/jats:styled-content>\n ) injection, and narrowband ultraviolet B (\n NB<\/jats:styled-content>\n \u2010\n UVB<\/jats:styled-content>\n ) for stable nonsegmental vitiligo regarding repigmentation grade, patient's satisfaction, and side effects.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Eighty adult patients with localized nonsegmental vitiligo were enrolled in this study. The patients were randomly categorized to receive 4 lines of treatment; fractional\n CO<\/jats:styled-content>\n 2<\/jats:sub>\n laser,\n PRP<\/jats:styled-content>\n , combined fractional\n CO<\/jats:styled-content>\n 2<\/jats:sub>\n laser and\n PRP<\/jats:styled-content>\n , and combined fractional\n CO<\/jats:styled-content>\n 2<\/jats:sub>\n laser and\n NB<\/jats:styled-content>\n \u2010\n UVB<\/jats:styled-content>\n . The treatment period was 2\u00a0months. Patients were clinically evaluated 3\u00a0months after the last treatment. Outcome was evaluated by 5\u2010point scale for repigmentation, 10\u2010point visual analog scale for patient's satisfaction, and side effects.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Laser and\n PRP<\/jats:styled-content>\n group achieved the best results regarding repigmentation and patient's satisfaction. Sixty percent of the patients developed repigmentation >50% and 40% of patients developed repigmentation >75%. In laser and\n NB<\/jats:styled-content>\n \u2010\n UVB<\/jats:styled-content>\n group, 5% developed repigmentation >75% and 25% developed repigmentation >50%. Only 10% of patients developed repigmentation >75% in laser group and only 20% of patients developed repigmentation >75% in\n PRP<\/jats:styled-content>\n group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Combination of fractional\n CO<\/jats:styled-content>\n 2<\/jats:sub>\n laser with\n PRP<\/jats:styled-content>\n injection is a promising treatment for vitiligo, followed by combination of fractional\n CO<\/jats:styled-content>\n 2<\/jats:sub>\n laser with\n NB<\/jats:styled-content>\n \u2010\n UVB<\/jats:styled-content>\n phototherapy. Both fractional\n CO<\/jats:styled-content>\n 2<\/jats:sub>\n laser and\n PRP<\/jats:styled-content>\n injection gave poor results if they received alone.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.12397","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T00:12:39Z","timestamp":1503274359000},"page":"365-372","source":"Crossref","is-referenced-by-count":65,"title":["Combined treatment with fractional carbon dioxide laser, autologous platelet\u2010rich plasma, and narrow band ultraviolet B for vitiligo in different body sites: A prospective, randomized comparative trial"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1590-8375","authenticated-orcid":false,"given":"Rania","family":"Abdelghani","sequence":"first","affiliation":[{"name":"Dermatology and Venereology Department Faculty of Medicine for Girls Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naglaa A","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Department Faculty of Medicine for Girls Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan M","family":"Darwish","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Department Faculty of Medicine for Girls Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00355.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.11.061"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijn.12179"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05097_9.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10160.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14356"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10723.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12202"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22260"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890480045006"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11197.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.07.053"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.09.004"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.14260\/Jemds\/2017\/366"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.10.043"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2003.12.003"},{"key":"e_1_2_7_18_1","first-page":"227","article-title":"Current 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