{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:00:05Z","timestamp":1790564405361,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,8,19]],"date-time":"2017-08-19T00:00:00Z","timestamp":1503100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic venous leg ulcers drastically reduce the quality of life of affected patients. There is heightened interest in autologous platelet\u2010rich plasma (<jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content>) as one of the promising therapies for leg ulcers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>Our aim was to compare the clinical efficacy of <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> in the management of chronic venous leg ulcers vs conventional treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>In total, 40 patients with chronic venous leg ulcers were included in the study. Twenty patients were treated with autologous <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> weekly for 6 weeks (Group A), and 20 patients were treated with conventional treatment (compression and dressing) for 6 weeks (Group B). Treatment results were calculated by percentage of improvement in area of the ulcer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to conventional therapy, a highly significant improvement in the ulcer size was observed post\u2010<jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> therapy (<jats:italic>P<\/jats:italic>\u2010value = .0001). The mean change in the area of the ulcer post\u2010<jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> and conventional therapy was 4.92 \u00b1 11.94 cm and 0.13 \u00b1 0.27 cm, respectively, while the mean percentage improvement in the area of the ulcer post\u2010<jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> and conventional therapy was 67.6% \u00b1 36.6% and 13.67% \u00b1 28.06%, respectively. Subjective improvement in pain associated with the ulcer was noted by all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Platelet\u2010rich plasma is a safe nonsurgical procedure for treating chronic venous leg ulcers. Additional studies with larger sample size and longer follow\u2010up periods are required to confirm or refute our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12401","type":"journal-article","created":{"date-parts":[[2017,8,20]],"date-time":"2017-08-20T03:56:36Z","timestamp":1503201396000},"page":"495-501","source":"Crossref","is-referenced-by-count":74,"title":["Autologous platelet\u2010rich plasma versus conventional therapy for the treatment of chronic venous leg ulcers: A comparative study"],"prefix":"10.1111","volume":"17","author":[{"given":"Hoda A","family":"Moneib","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar S","family":"Youssef","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3647-8618","authenticated-orcid":false,"given":"Dalia G","family":"Aly","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology National Research Centre Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A","family":"Rizk","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yomna I","family":"Abdelhakeem","sequence":"additional","affiliation":[{"name":"Al Haud Almarsoud Hospital Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.10.048"},{"key":"e_1_2_6_3_1","first-page":"256","article-title":"Platelet\u2010rich plasma in skin ulcer treatment","volume":"25","author":"Cobos Campos R","year":"2013","journal-title":"Wounds"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"e007733","DOI":"10.1136\/bmjopen-2015-007733","article-title":"Exploratory clinical trial of combination wound therapy with a gelatin sheet and platelet\u2010rich plasma in patients with chronic skin ulcers: study protocol","volume":"11","author":"Morimoto N","year":"2015","journal-title":"BMJ Open"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-014-0211-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2012.1230"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12777"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.112671"},{"issue":"5","key":"e_1_2_6_9_1","article-title":"Autologous platelet\u2010rich plasma for treating chronic wounds","author":"Martinez\u2010Zapata MJ","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2011.00797.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-2196"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000222526.21512.4c"},{"key":"e_1_2_6_13_1","first-page":"68","article-title":"Autologel diabetic foot ulcer study group. 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