{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:28:04Z","timestamp":1740126484661,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Androgenetic alopecia (<jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>) is the most common hair loss. The 2D:4D digit ratio refers to the ratio of the length of the second finger to that of the fourth finger and is thought as a marker of prenatal androgen exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>There are many studies which have examined the relationship between 2D:4D ratio and some other diseases. In this study, we evaluated the relationship between digit ratio 2D:4D and <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study group was composed of a male with <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> and healthy controls. The lengths of patients\u2019 second and fourth fingers were measured using a digital caliper with a resolution of 0.01 mm. Finger length was measured on the palmar side of the hand from the basal metacarpophalangeal crease. The 2D:4D ratio was obtained by dividing the length of the second finger by the length of the fourth finger.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 99 males who have androgenetic alopecia with a score of grade <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> or more and 90 controls were included. The mean age of <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> group was 29.72 \u00b1 5.53, and the mean age of control group was 19.63 \u00b1 5.05. The left\u2010hand 2D:4D ratios of <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> group (0.893 \u00b1 0.267) were significantly lower than healthy controls (0.971 \u00b1 0.028). No significant relationships were found between <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> severity, age of onset,and digit ratios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The left\u2010hand digit ratio 2D:4D is lower in <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> patients, and therefore, left\u2010hand digit ratio 2D:4D can be used as an estimation tool for <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> development in future. There is not any correlation between digit ratio and age of onset. Also, there is no correlation between digit ratio 2D:4D and <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12403","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T08:05:35Z","timestamp":1504166735000},"page":"545-548","source":"Crossref","is-referenced-by-count":5,"title":["Digit ratio 2D:4D is a possible indicator for androgenetic alopecia in males"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8964-3314","authenticated-orcid":false,"given":"Mehmet","family":"Unal","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Sel\u00e7uk University Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"issue":"1","key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4274\/turkderm.48.s8","article-title":"Male androgenetic alopecia","volume":"48","author":"Kutlubay Z","year":"2014","journal-title":"Turkderm"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20164622"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.4081\/dr.2016.6386"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12594"},{"key":"e_1_2_5_6_1","first-page":"72","article-title":"Relative index finger length as a sexinfluenced trait in man","volume":"4","author":"Phelps VR","year":"1952","journal-title":"Am J Hum Genet"},{"key":"e_1_2_5_7_1","first-page":"5","article-title":"Digit ratio (2D:4D): a biomarker for prenatal sex steroids and adult sex steroids in challenge situations","volume":"30","author":"Manning J","year":"2014","journal-title":"Front Endocrinol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.11.3000"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(02)00073-7"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1677-55382012000500005"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12287"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2013.10.003"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2012.08.009"},{"key":"e_1_2_5_14_1","first-page":"9","article-title":"Second to fourth digit ratio (2D:4D) and concentrations of circulating sex hormones in adulthood","volume":"27","author":"Muller DC","year":"2011","journal-title":"Reprod Biol Endocrinol"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000710306"},{"key":"e_1_2_5_16_1","first-page":"339","volume-title":"Hair research for the next millennium","author":"Russel DW","year":"1996"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-4-17"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.1998.1503"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-015-0147-3"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12403","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:30:43Z","timestamp":1695490243000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,29]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/jocd.12403"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12403","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"subject":[],"published":{"date-parts":[[2017,8,29]]}}}