{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:35:54Z","timestamp":1764401754970,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31271264","31400883"],"award-info":[{"award-number":["31271264","31400883"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Xanthelasma is the most common type of cutaneous xanthoma and often occurs on the eyelids. Xanthoma has been reported to be highly correlated with abnormal lipoprotein metabolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>In this study, we wanted to investigate the effects of a high\u2010cholesterol diet on xanthoma formation and lipoprotein metabolism in rabbits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In animals fed with high\u2010cholesterol diet, deteced plasma lipid [ie, total cholesterol (TC), triglycerides (TG), and low\u2010density lipoprotein cholesterol (L\u2010DLC)] levels and pathology of xanthoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plasma lipid levels were dramatically elevated within 8 weeks. In addition, high dietary cholesterol promoted xanthoma formation on the napex. Microscopic examination showed that foam cells laden with cholesterol deposits accumulated around the dermal capillaries and cutaneous appendages within the skin of the napex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings indicate a critical role for a high\u2010cholesterol diet in the dysregulation of lipoprotein metabolism and the development of xanthoma in rabbits. The results suggest that abnormal lipid metabolism may increase the occurrence of xanthoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12428","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T05:22:57Z","timestamp":1507699377000},"page":"885-888","source":"Crossref","is-referenced-by-count":6,"title":["Effect of a high\u2010cholesterol diet on lipoprotein metabolism and xanthoma formation in rabbits"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1123-020X","authenticated-orcid":false,"given":"Hao","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Changzheng Hospital Second Military Medical University Shanghai China"},{"name":"The Hospital of Beijing Armed Police Forces Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yak","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Changzheng Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Tang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Beijing Armed Police Forces Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaozh","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Changzheng Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Changzheng Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Changzheng Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,11]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1097\/00006534-200210000-00016"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1016\/S0190-9622(94)70023-0"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1097\/DSS.0000000000000660"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1046\/j.1365-2230.2000.00655-3.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1111\/j.1365-2230.2010.03818.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1111\/j.1524-4725.2010.01770.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1016\/j.oftal.2011.12.007"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1023\/B:INTE.0000018523.55861.6c"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1111\/j.1365-2133.2007.08194.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.1002\/lsm.1117"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.1111\/j.1524-4725.2010.01514.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_1","DOI":"10.5999\/aps.2013.40.4.380"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_1","DOI":"10.1055\/s-0029-1245829"},{"key":"e_1_2_8_15_1","first-page":"339","article-title":"Lipid metabolism in xanthomatous skin of hypercholesterolemic rabbits","volume":"125","author":"Armstrong ML","year":"1986","journal-title":"Am J Pathol"},{"key":"e_1_2_8_16_1","first-page":"891","article-title":"Effective treatment of xanthelasma","volume":"15","author":"Sansalone K","year":"2016","journal-title":"J Drugs Dermatol"},{"doi-asserted-by":"publisher","key":"e_1_2_8_17_1","DOI":"10.1016\/j.sjopt.2014.09.017"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.12428","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.12428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T21:25:15Z","timestamp":1694899515000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.12428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,11]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/jocd.12428"],"URL":"https:\/\/doi.org\/10.1111\/jocd.12428","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"subject":[],"published":{"date-parts":[[2017,10,11]]}}}