{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:01:06Z","timestamp":1774540866955,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T00:00:00Z","timestamp":1505865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Organic silicon plays an important role in dermal structure by promoting neocollagenesis. Thus, the supplementation of silicon in a highly bioavailable form can be used for skin rejuvenation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to evaluate skin changes associated with the use of ortho\u2010silicic acid stabilized by hydrolyzed collagen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Patients were randomized to receive 600\u00a0mg of ortho\u2010silicic acid stabilized by hydrolyzed collagen (group 1, n\u00a0=\u00a011) or placebo (group 2, n\u00a0=\u00a011) to be taken 15\u00a0minutes before breakfast for 90\u00a0days. Clinical, photographical, and patients\u2019 subjective evaluations were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 22 patients were included. Clinical evaluations demonstrated changes in skin texture, firmness, and hydration statistically superior in group 1. Brightness, firmness, and overall appearance showed trends for a difference favoring group 1 according to patients\u2019 subjective evaluations. Objective images showed no statistical differences. No side effects, hypersensitivity, or systemic symptoms were observed in group 1. Treatment satisfaction in group 1 reached 80%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ortho\u2010silicic acid stabilized by hydrolyzed collagen in a daily dose of 600\u00a0mg showed positive results in skin rejuvenation according to clinical evaluation in firmness, hydration, and skin texture. Further studies with larger and representative samples should be conducted to confirm our results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.12430","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T04:08:41Z","timestamp":1505966921000},"page":"814-820","source":"Crossref","is-referenced-by-count":17,"title":["Evaluation of cutaneous rejuvenation associated with the use of ortho\u2010silicic acid stabilized by hydrolyzed marine collagen"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1294-547X","authenticated-orcid":false,"given":"C\u00e9lia Luiza","family":"Petersen Vitello Kalil","sequence":"first","affiliation":[{"name":"C\u00e9lia Kalil Dermatologic Clinic Porto Alegre\u2014Rio Grande de Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria","family":"Campos","sequence":"additional","affiliation":[{"name":"Val\u00e9ria Campos Dermatologic Clinic Jundia\u00ed\u2014S\u00e3o 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